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Tizerpatide Glycine Compounding

Tirzepatide / Glycine

(Ship Cold) Injection

16.6 mg / 7.5 mg / mL

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Product Overview

Tirzepatide / Glycine Injection Description1-4

Tirzepatide / Glycine Injection is a combination formulation containing tirzepatide and glycine. Tirzepatide functions as a dual incretin receptor agonist, targeting both glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors, while glycine is an amino acid involved in protein synthesis.

Tirzepatide1-3

Tirzepatide is administered as a once-weekly subcutaneous injection and is used alongside diet and exercise to support glycemic control in adults with type 2 diabetes mellitus. It is also FDA approved for chronic weight management under the brand name Zepbound in specific populations. Tirzepatide is a novel dual agonist of GIP and GLP-1 receptors.

Glycine5-9

Glycine is an amino acid that can be produced endogenously by the body. It is a structural component of many proteins, including collagen, creatine, and purine nucleotides. In plasma, glycine represents approximately 11.5% of the total amino acid content. It has been studied in marathon runners for its anti-inflammatory and immunomodulatory properties, as well as its potential effects on physical performance and muscle development. Glycine has also been reported to play a role in the prevention of lung injury, gastric ulcers, and in conditions involving hemorrhagic and endotoxic shock.
References
  1. Clinical Pharmacology powered by Elsevier (ClinicalKey) – Tirzepatide Monograph. https://www.clinicalkey.com

  2. FDA Prescribing Information – Mounjaro® (tirzepatide): https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/215866s000lbl.pdf

  3. Jastreboff AM, et al. “Tirzepatide Once Weekly for the Treatment of Obesity.” NEJM. 2022; 387(3):205–216. https://www.nejm.org/doi/full/10.1056/NEJMoa2206038

  4. Drucker DJ. “Mechanisms of Action and Therapeutic Application of GLP-1 and GIP.” Cell Metabolism. 2018. https://doi.org/10.1016/j.cmet.2018.06.015
  5. Ramos-Jiménez A, Hernández-Torres RP, Hernández-Ontiveros DA, Ortiz-Ortiz M, López-Fregoso RJ, Martínez-Sanz JM, Rodríguez-Uribe G, Hernández-Lepe MA. An Update of the Promise of Glycine Supplementation for Enhancing Physical Performance and Recovery. Sports (Basel). 2024 Sep 25;12(10):265.
  6. Aguayo-Cerón KA, Sánchez-Muñoz F, Gutierrez-Rojas RA, Acevedo-Villavicencio LN, Flores-Zarate AV, Huang F, Giacoman-Martinez A, Villafaña S, Romero-Nava R. Glycine: The Smallest Anti-Inflammatory Micronutrient. Int J Mol Sci. 2023 Jul 8;24(14):11236.
  7. Razak MA, Begum PS, Viswanath B, Rajagopal S. Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review. Oxid Med Cell Longev. 2017;2017:1716701.
  8. Glycine-adverse reaction overview. https://ontosight.ai/glossary/term/glycine-adverse-reaction-overview–67a164126c3593987a56a572. Accessed June 25, 2025
  9. Glycine – Professional Monograph; NatMed Pro ; 2025 ; https://naturalmedicines.therapeuticresearch.com/Data/ProMonographs/Glycine

Tirzepatide1-3

Tirzepatide exerts its effects through dual incretin receptor agonism, targeting both:

  1. GIP (Glucose-dependent Insulinotropic Polypeptide) Receptor:

  • Enhances insulin secretion
  • Reduces glucagon secretion
  • Promotes lipid metabolism and may contribute to weight loss
  1. GLP-1 (Glucagon-Like Peptide-1) Receptor:

  • Delays gastric emptying
  • Reduces appetite
  • Stimulates insulin release in a glucose-dependent manner
  • Inhibits glucagon release during hyperglycemia

 

Glycine5-9

Glycine exerts its anti-inflammatory effects by inhibiting cytokine synthesis, reducing serum transaminase levels and works on decreasing calcium levels inside cells. The cytokines that glycine inhibits are TNF-a, interleukin-6, interleukin-1b. It also increases the levels of anti-inflammatory cytokines including interleukin-10 found in macrophages and leucocytes.

Adverse Reactions 1-4,8

Most adverse reactions are gastrointestinal in nature and dose-dependent:

  • Gastrointestinal: Nausea, vomiting, diarrhea, constipation, dyspepsia, decreased appetite, abdominal pain
  • Headache, dizziness, and injection site reactions

Contraindications & Precautions 1-4

Contraindications:

  • Personal or family history of medullary thyroid carcinoma (MTC)
  • Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
  • History of serious hypersensitivity to tirzepatide or any component of the formulation
  • Nonketotic hyperglycinemia (NKH) or other genetic disorders preventing absorption of amino acids.

Precautions:

  • Pancreatitis risk: Monitor patients for signs/symptoms (serious abdominal pain)
  • Severe gastrointestinal disease: Use with caution; only if benefit outweighs potential risk.
  • Acute kidney injury: Especially in those with dehydration, vomiting, or diarrhea.
  • Diabetic retinopathy: Rapid improvement in glucose may worsen retinopathy.
  • Use with insulin or secretagogues: Dose adjustment may be necessary to reduce hypoglycemia risk.

Pregnancy & Lactation:
- No adequate data; use only if benefit outweighs potential risk.
 Discontinue at least 1 month prior to a planned pregnancy due to long half-life

Store refrigerated at 36°F to 46°F (2°C – 8°C). Discard within 28 days of puncture or according to the beyond-use date. Do not freeze. Keep out of reach of children.

  1. Clinical Pharmacology powered by Elsevier (ClinicalKey) – Tirzepatide Monograph. https://www.clinicalkey.com

  2. FDA Prescribing Information – Mounjaro® (tirzepatide): https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/215866s000lbl.pdf

  3. Jastreboff AM, et al. “Tirzepatide Once Weekly for the Treatment of Obesity.” NEJM. 2022; 387(3):205–216. https://www.nejm.org/doi/full/10.1056/NEJMoa2206038

  4. Drucker DJ. “Mechanisms of Action and Therapeutic Application of GLP-1 and GIP.” Cell Metabolism. 2018. https://doi.org/10.1016/j.cmet.2018.06.015
  5. Ramos-Jiménez A, Hernández-Torres RP, Hernández-Ontiveros DA, Ortiz-Ortiz M, López-Fregoso RJ, Martínez-Sanz JM, Rodríguez-Uribe G, Hernández-Lepe MA. An Update of the Promise of Glycine Supplementation for Enhancing Physical Performance and Recovery. Sports (Basel). 2024 Sep 25;12(10):265.
  6. Aguayo-Cerón KA, Sánchez-Muñoz F, Gutierrez-Rojas RA, Acevedo-Villavicencio LN, Flores-Zarate AV, Huang F, Giacoman-Martinez A, Villafaña S, Romero-Nava R. Glycine: The Smallest Anti-Inflammatory Micronutrient. Int J Mol Sci. 2023 Jul 8;24(14):11236.
  7. Razak MA, Begum PS, Viswanath B, Rajagopal S. Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review. Oxid Med Cell Longev. 2017;2017:1716701.
  8. Glycine-adverse reaction overview. https://ontosight.ai/glossary/term/glycine-adverse-reaction-overview–67a164126c3593987a56a572. Accessed June 25, 2025
  9. Glycine – Professional Monograph; NatMed Pro ; 2025 ; https://naturalmedicines.therapeuticresearch.com/Data/ProMonographs/Glycine
This information is for educational purposes only.
This compounded product has not been reviewed, approved, or evaluated by the Food and Drug Administration for safety and effectiveness. This product is not intended to diagnose, treat, cure, or prevent any disease. No claims are made regarding treatment, cure, or prevention of any disease or condition.
This information is a summary. It may not cover all possible drug information about this product. For complete product information, refer to the manufacturer’s prescribing information and labeling. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A WP Pharma Labs pharmacist will be happy to answer any questions. For consultation, please call 1-800-441-0048.

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