DHEA-7-Keto SR K100M

Capsule

100 mg

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Product Overview

DHEA-7-Keto SR K100M Description1-4

7-Keto-DHEA is a naturally occurring metabolite of dehydroepiandrosterone (DHEA). Unlike DHEA, it does not convert into sex hormones such as testosterone or estradiol. Evidence suggests potential effectiveness in areas including weight management, metabolic support, immune function, and cognitive performance.

References

  1. 7-Keto DHEA – Patient Handout; NatMed Pro; 2025; https://naturalmedicines-therapeuticresearch-com.lp.hscl.ufl.edu/databases/food,-herbs-supplements/patienthandout.aspx?productid=835&lang=en
  2. 7-Keto DHEA – Professional Monograph; NatMed Pro; 2025; https://naturalmedicines-therapeuticresearch-com.lp.hscl.ufl.edu/databases/food,-herbs-supplements/professional.aspx?productid=835
  3. Douglas S. Kaiman, Carlon M. Colker, Melissa A. Swain, Georgeann C. Torina, Qiuhu Shi. A randomized, double-blind, placebo-controlled study of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy overweight adults. Current Therapeutic Research. Volume 61, Issue 7, 2000, 435-442.
  4. Jeyaprakash N, Maeder S, Janka H, Stute P. A systematic review of the impact of 7-keto-DHEA on body weight. Arch Gynecol Obstet. 2023 Sep;308(3):777-785.

Mechanism of Action1,2

7-Keto-DHEA is believed to enhance thermogenesis (heat production) and basal metabolic rate by modulating the activity of 3 key metabolic enzymes, including: Glycerol-3-phosphate dehydrogenase, cytosolic malic enzyme, citrate lyase.

These enzymes influence fatty acid oxidation and mitochondrial efficiency, contributing to increased energy expenditure by cells.

Adverse Reactions1,2

  • Headache
  • Nausea or gastrointestinal upset
  • Mild dizziness
  • Irritability
  • Sleep disturbances (less common)
  • Because it does not convert into sex hormones, androgenic side effects (e.g., acne, hair loss, hirsutism) are rare or absent

Contraindications1,2

  • Hypersensitivity to 7-keto-DHEA or any excipients in the product.
  • Pregnancy or breastfeeding (insufficient safety data).

Precautions1,2

  • Use caution in individuals with autoimmune diseases due to theoretical immune-enhancing effects.
  • May interfere with thyroid function tests (e.g., T3/T4 levels); however, clinical significance is unclear.
  • People with hormone-sensitive conditions may still want to consult a healthcare provider, even though 7-keto-DHEA lacks direct hormonal activity.
  • Safety in children and adolescents has not been established.
  • Store at controlled room temperature (20°C to 25°C / 68°F to 77°F)
  • Protect from moisture and light
  • Keep in a tightly closed container
  1. 7-Keto DHEA – Patient Handout; NatMed Pro; 2025; https://naturalmedicines-therapeuticresearch-com.lp.hscl.ufl.edu/databases/food,-herbs-supplements/patienthandout.aspx?productid=835&lang=en
  2. 7-Keto DHEA – Professional Monograph; NatMed Pro; 2025; https://naturalmedicines-therapeuticresearch-com.lp.hscl.ufl.edu/databases/food,-herbs-supplements/professional.aspx?productid=835
  3. Douglas S. Kaiman, Carlon M. Colker, Melissa A. Swain, Georgeann C. Torina, Qiuhu Shi. A randomized, double-blind, placebo-controlled study of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy overweight adults. Current Therapeutic Research. Volume 61, Issue 7, 2000, 435-442.
  4. Jeyaprakash N, Maeder S, Janka H, Stute P. A systematic review of the impact of 7-keto-DHEA on body weight. Arch Gynecol Obstet. 2023 Sep;308(3):777-785.
This information is for educational purposes only.
This compounded product has not been reviewed, approved, or evaluated by the Food and Drug Administration for safety and effectiveness. This product is not intended to diagnose, treat, cure, or prevent any disease. No claims are made regarding treatment, cure, or prevention of any disease or condition.
This information is a summary. It may not cover all possible drug information about this product. For complete product information, refer to the manufacturer’s prescribing information and labeling. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A WP Pharma Labs pharmacist will be happy to answer any questions. For consultation, please call 1-800-441-0048.

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