Facial Gel
0.3% / 0.5%
Product Overview Coming Soon
Product Overview
Estriol Description1-5
Micronized estriol is a bioidentical form of estriol (E3), one of the three naturally occurring estrogens in women, along with estradiol and estrone. Estriol is considered the weakest estrogen, with lower receptor binding affinity and a shorter duration of action compared to estradiol (E2). Despite its lower potency, estriol has been associated with skin-related properties, including effects on dermal thickness and elasticity. It is most commonly used in combination with estradiol in postmenopausal women with estrogen deficiency. Estriol may also be compounded with other ingredients into a gel formulation.
Hyaluronic Acid Description6,7
Hyaluronic acid is a glycosaminoglycan that plays an important role in the skin. It contributes to hydration, elasticity, and overall skin integrity, and it is also involved in wound healing. With aging, hyaluronic acid production declines, which is associated with drier skin and reduced elasticity.
References
Estriol1-5
Estriol acts by binding to estrogen receptors alpha (ERα) and beta (ERβ) in estrogen-responsive tissues, particularly the vaginal epithelium, bladder, urethra, and pelvic floor musculature.
Mechanism and Effects:
Hyaluronic Acid6,7
Hyaluronic acid may have the following two mechanisms for its activity on the skin: 1) as a passive structural molecule and 2) as a signaling molecule (based on its molecular size). Hyaluronic acid has hydgroscopicity and viscoelasticity properties. It is highly anionic that can attract water. This attraction of water provides the ability of the skin to create volume and provide structural support. The signaling mechanism may be facilitated by its anti-inflammatory properties through its effects on cell migration and cell division.
Estrogen1-5
Common
Systemic (estriol) (rare at low doses):
Hyaluronic Acid8
Common
Contraindications1-5,8
Precautions1-5,8
Use caution in:
Store at 20°C to 25°C (68°F to 77°F) in a dry place, away from heat and light. Keep out of reach of children.
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