Hard-Tab (mint)
20 mg / 8 mg
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Product Overview
Tadalafil1-3
Tadalafil is a phosphodiesterase type 5 (PDE5) inhibitor with a mean terminal half-life exceeding 17 hours, which is considerably longer than that of other PDE5 inhibitors. This extended half-life allows for either once-daily or on-demand dosing. Tadalafil is indicated for the treatment of pulmonary arterial hypertension (PAH), erectile dysfunction (ED), benign prostatic hyperplasia (BPH), or for the concurrent management of ED and BPH.
Vardenafil4-6
Vardenafil is a potent and highly selective oral PDE5 inhibitor with a mean terminal half-life of 4 to 6 hours. It is generally well tolerated and is indicated for the treatment of erectile dysfunction, typically used on an on-demand basis.
References
Tadalafil,2,3
Phosphodiesterase (PDE) has many isoforms and is an enzyme that has many functions in the body including degrading the effect of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). PDE5 is an enzyme that is found in many parts of the body including in the smooth muscle of the corpus cavernosum, prostate, bladder, the vascular and visceral smooth muscle, skeletal muscle, urethra, platelets, kidney, lung, cerebellum, heart, liver, testis, seminal vesicle, and pancreas. Tadalafil is a selective inhibitor of PDE5, the enzyme responsible for the degradation of cGMP. The drug has selective activity on PDE5 than other phosphodiesterase isoforms. Tadalafil activity on PDE5 is more than 10,000-fold more than for PDE1, PDE2, PDE4, and PDE7 enzymes. Increased cGMP leads to smooth muscle relaxation in the corpus cavernosum which can help in maintaining an erection.
Vardenafil4-6
Phosphodiesterase (PDE) has many isoforms and is an enzyme that has many functions in the body including degrading the effect of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). PDE5 is an enzyme that is found in many parts of the body including in the smooth muscle of the corpus cavernosum, prostate, bladder, the vascular and visceral smooth muscle, skeletal muscle, urethra, platelets, kidney, lung, cerebellum, heart, liver, testis, seminal vesicle, and pancreas. Vardenafil is a selective inhibitor of PDE5, the enzyme responsible for the degradation of cGMP. Vardenafil’s activity on PDE5 has been shown to be approximately 10 fold to 25 fold more than sildenafil. Increased cGMP leads to smooth muscle relaxation in the corpus cavernosum which can help in maintaining an erection.
Common
Tadalafil1,2
Vardenafil4,5
Contraindications 1,2,4,5
Precautions 1,2,4,5
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