Sermorelin / Theanine

Rapid Dissolve Mini-Tabs

300 mcg / 2.5 mg

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Product Overview

Sermorelin Description1-6

Sermorelin is a synthetic peptide analog of endogenous growth hormone–releasing hormone (GHRH), comprising the first 29 amino acids of the 44-residue natural human GHRH. It is used both as a diagnostic agent and as a growth hormone secretagogue to stimulate the pituitary gland’s endogenous production of human growth hormone (hGH).

Theanine Description7-10

Theanine is a non-protein amino acid first identified in green tea in 1949. It is also present in other teas, including black and white varieties, as well as in certain mushrooms. Structurally, theanine resembles the neurotransmitters glutamine and gamma-aminobutyric acid (GABA), and, like them, it can cross the blood–brain barrier. Theanine has a naturally caramel-like flavor and can help reduce the bitter taste of caffeine. It is also associated with a variety of pharmacological properties, including antioxidant, anti-inflammatory, neuroprotective, anti-cancer, anti-anxiety, metabolic, cardiovascular, liver and kidney protective, and immune-supporting effects.

References

  1. Walker RF. Sermorelin: a better approach to management of adult-onset growth hormone insufficiency? Clin Interv Aging. 2006;1(4):307-8. doi: 10.2147/ciia.2006.1.4.307. PMID: 18046908; PMCID: PMC2699646.
  2. RxList. Sermorelin Acetate Injection. https://www.rxlist.com/sermorelin-acetate-drug.htm
  3. Bianco AC, et al. “Physiology of the GHRH–GH–IGF1 axis.” Endocr Rev. 2002;23(1):38–89.
  4. Drugs.com. Sermorelin Acetate; accesses June 27 2025; https://www.drugs.com/cdi/sermorelin-acetate.html
  5. Walker RF. “Clinical utility of growth hormone-releasing peptides.” Drugs. 1994;47(2):269-273. PubMed PMID: 7517376
  6. Geref Description Archive.(discontinued product); accessed June 26 2025;  https://worldhealth.net/news/geref_seristim/ 
  7. Dashwood R, Visioli F. l-theanine: From tea leaf to trending supplement – does the science match the hype for brain health and relaxation? Nutr Res. 2025 Feb;134:39-48.
  8. Theanine-Uses, Side effects, and more. https://www.webmd.com/vitamins/ai/ingredientmono-1053/theanine#overview. Accessed July 20, 2025
  9. Li MY, Liu HY, Wu DT, Kenaan A, Geng F, Li HB, Gunaratne A, Li H, Gan RY. L-Theanine: A Unique Functional Amino Acid in Tea (Camellia sinensis L.) With Multiple Health Benefits and Food Applications. Front Nutr. 2022 Apr 4;9:853846.
  10. Priya A. J., Lakshminarayanan A., Devi R. G, Ganesh M.K,Kumar S. A detailed approach on the health benefits of L-theanine. Biomedicine: 2019; 39(3): 394- 399.

Sermorelin1-6

Sermorelin acts as an agonist at the GHRH receptor in the anterior pituitary, stimulating somatotroph cells to increase the synthesis and pulsatile release of endogenous growth hormone (GH). This in turn stimulates the liver to produce insulin-like growth factor-1 (IGF-1), which mediates many of the anabolic and metabolic effects associated with human growth hormone.

Unlike exogenous recombinant human growth hormone (rhGH), sermorelin stimulates physiologic GH production while preserving feedback regulation via somatostatin and IGF-1 pathways. This supports a more natural circadian rhythm of GH release

Theanine7-10

Theanine activity supports many different mechanisms of activity. As an antioxidant, theanine decreases reactive oxygen species development and increases the activity of antioxidant enzymes to decrease oxidative damage. As an anti-inflammatory, theanine decreases proinflammatory factors, including cyclooxygenase-2, prostaglandin E2, nitric oxide synthase, and nitric oxide. Theanine has been shown to be neuroprotective stimulating the release of glutathione. In addition, theanine has been shown to have a relaxing effect and help induce sleep and sleep duration. It increases GABA, serotonin, and dopamine to affect mood regulation. Thus, there is evidence to show that it has a role in helping depression and stress, as well as emotional and cognitive function. Theanine has been shown to increase cancer cell apoptosis and decrease cancer cell growth, decrease liver cirrhosis, decrease nephrotoxicity, and decrease vascular remodeling.

Common

Sermorelin1-6  

  • Facial flushing
  • Headache
  • Nausea
  • Dizziness
  • Sleep disturbances (insomnia or drowsiness)

 

Theanine8

  • Headache
  • Sleepiness

Sermorelin1-6

Contraindications:

  • Hypersensitivity to sermorelin or any component of the formulation
  • Active malignancies, particularly those influenced by GH or IGF-1
  • Intracranial lesion
  • Use during pregnancy and breastfeeding not recommended (due to insufficient safety data)

Precautions:

  • Use with caution in patients with a history of cancer or intracranial lesions
  • May unmask latent diabetes mellitus due to its GH-stimulating properties

 

Theanine8

Contraindications:

  • Hypersensitivity or intolerance to theanine
  • Use during pregnancy and breastfeeding not recommended (due to insufficient safety data)

Precautions

  • Generally well tolerated
  • Store at controlled room temperature (20°C to 25°C / 68°F to 77°F)
  • Protect from moisture and light
  • Keep in a tightly closed container
  1. Walker RF. Sermorelin: a better approach to management of adult-onset growth hormone insufficiency? Clin Interv Aging. 2006;1(4):307-8. doi: 10.2147/ciia.2006.1.4.307. PMID: 18046908; PMCID: PMC2699646.
  2. RxList. Sermorelin Acetate Injection. https://www.rxlist.com/sermorelin-acetate-drug.htm
  3. Bianco AC, et al. “Physiology of the GHRH–GH–IGF1 axis.” Endocr Rev. 2002;23(1):38–89.
  4. Drugs.com. Sermorelin Acetate; accesses June 27 2025; https://www.drugs.com/cdi/sermorelin-acetate.html
  5. Walker RF. “Clinical utility of growth hormone-releasing peptides.” Drugs. 1994;47(2):269-273. PubMed PMID: 7517376
  6. Geref Description Archive.(discontinued product); accessed June 26 2025;  https://worldhealth.net/news/geref_seristim/ 
  7. Dashwood R, Visioli F. l-theanine: From tea leaf to trending supplement – does the science match the hype for brain health and relaxation? Nutr Res. 2025 Feb;134:39-48.
  8. Theanine-Uses, Side effects, and more. https://www.webmd.com/vitamins/ai/ingredientmono-1053/theanine#overview. Accessed July 20, 2025
  9. Li MY, Liu HY, Wu DT, Kenaan A, Geng F, Li HB, Gunaratne A, Li H, Gan RY. L-Theanine: A Unique Functional Amino Acid in Tea (Camellia sinensis L.) With Multiple Health Benefits and Food Applications. Front Nutr. 2022 Apr 4;9:853846.
  10. Priya A. J., Lakshminarayanan A., Devi R. G, Ganesh M.K,Kumar S. A detailed approach on the health benefits of L-theanine. Biomedicine: 2019; 39(3): 394- 399.
This information is for educational purposes only.
This compounded product has not been reviewed, approved, or evaluated by the Food and Drug Administration for safety and effectiveness. This product is not intended to diagnose, treat, cure, or prevent any disease. No claims are made regarding treatment, cure, or prevention of any disease or condition.
This information is a summary. It may not cover all possible drug information about this product. For complete product information, refer to the manufacturer’s prescribing information and labeling. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A WP Pharma Labs pharmacist will be happy to answer any questions. For consultation, please call 1-800-441-0048.

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