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DHEA SR in K100M Description1-3
Dehydroepiandrosterone (DHEA) is an endogenous steroid hormone produced mainly by the adrenal cortex, with smaller amounts synthesized in the gonads and the brain. It acts as a precursor to both androgens and estrogens, including testosterone and estradiol. DHEA levels naturally decrease with age, and supplementation is used in contexts such as age-related hormonal decline, adrenal insufficiency, mood support, and sexual health.
Transdermal DHEA may be compounded into a cream or gel for application to the skin, enabling systemic absorption while bypassing first-pass hepatic metabolism. This route of administration may help minimize side effects and support more consistent hormone levels compared with oral DHEA.
References
Mechanism of Action1-3
DHEA is a prohormone, meaning its physiological effects are largely mediated through conversion to active androgens (like testosterone) and estrogens (like estradiol).
Endocrine effects:
In peripheral tissues, DHEA is converted to androstenedione, then to testosterone, estrone, and estradiol via tissue-specific enzymes such as 3β-HSD, 17β-HSD, aromatase.
Neurosteroid activity:
DHEA may interact with GABA-A and NMDA receptors, contributing to its neuromodulatory, antidepressant, and anxiolytic properties.
Contraindications1-3
Precautions1-3
Mild to moderate1-3
Less common but notable1-3
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