Enclomiphene Citrate

Capsules

5 mg | 12.5 mg | 25 mg | 50 mg

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Product Overview Coming Soon

Product Overview

Product Description

Enclomiphene Citrate Description^1-4

Enclomiphene citrate is a nonsteroidal selective estrogen receptor modulator (SERM) derived from clomiphene citrate. While clomiphene is a racemic mixture containing both enclomiphene (the trans-isomer) and zuclomiphene (the cis-isomer), enclomiphene consists solely of the trans-isomer. Due to its ability to stimulate endogenous testosterone production, enclomiphene is being considered for the management of secondary hypogonadism in men, particularly in cases where preservation of fertility is desired.

References

Kassab J, Saffati G, Lipshultz L, Khera M. Safety and Efficacy of Enclomiphene Compared to Clomiphene for Hypogonadal Men. J Sex Med. 2024;21(Supplement_1):qdae001.090. https://doi.org/10.1093/jsxmed/qdae001.090
Rodriguez KM, Pastuszak AW, Lipshultz LI. Enclomiphene citrate for the treatment of secondary male hypogonadism. Expert Opin Pharmacother. 2016;17(11):1561–7. doi:10.1080/14656566.2016.1204294
Thomas J, et al. Efficacy of Clomiphene Citrate Versus Enclomiphene Citrate for Male Infertility Treatment: A Retrospective Study. Cureus. 2023;15(7):e41476. doi:10.7759/cureus.41476
Wiehle R, et al. Testosterone Restoration by Enclomiphene Citrate in Men with Secondary Hypogonadism: Pharmacodynamics and Pharmacokinetics. BJU Int. 2013;112(8):1188–1200. doi:10.1111/bju.12363

Product Mechanism of Action

Mechanism of Action^1-4

Enclomiphene works by antagonizing estrogen receptors in the hypothalamus, thereby reducing negative feedback inhibition on the hypothalamic-pituitary-gonadal (HPG) axis. This leads to:

Increased GnRH secretion (from the hypothalamus)
Stimulation of LH and FSH release (from the anterior pituitary)
Subsequent endogenous testosterone production and spermatogenesis (via Leydig and Sertoli cell activation)

Product Adverse Reactions

Common^1-4

Most side effects are mild and transient, but may include:

Headache
Nausea
Mood changes or irritability
Gynecomastia or breast tenderness
Acne or oily skin
Elevated hematocrit or hemoglobin (monitor if long-term use)

Product Contraindications & Precautions

Contraindications^1-4

Known hypersensitivity to enclomiphene or other SERMs
Active or previous history of hormone-sensitive cancers (e.g., prostate or breast cancer)
Severe liver disease
Uncontrolled thromboembolic disorders

Precautions^1-4

Regular monitoring of serum testosterone, estradiol, LH, and FSH is advised
Assess sperm parameters in men using for fertility support
Use caution in men with cardiovascular disease or sleep apnea
Enclomiphene may increase testosterone beyond physiologic levels if overused
Discontinue if vision changes or thromboembolic symptoms occur

Product Storage

Store at controlled room temperature (20°C to 25°C / 68°F to 77°F)
Protect from moisture and light
Keep in a tightly closed container

Product References

Kassab J, Saffati G, Lipshultz L, Khera M. Safety and Efficacy of Enclomiphene Compared to Clomiphene for Hypogonadal Men. J Sex Med. 2024;21(Supplement_1):qdae001.090. https://doi.org/10.1093/jsxmed/qdae001.090
Rodriguez KM, Pastuszak AW, Lipshultz LI. Enclomiphene citrate for the treatment of secondary male hypogonadism. Expert Opin Pharmacother. 2016;17(11):1561–7. doi:10.1080/14656566.2016.1204294
Thomas J, et al. Efficacy of Clomiphene Citrate Versus Enclomiphene Citrate for Male Infertility Treatment: A Retrospective Study. Cureus. 2023;15(7):e41476. doi:10.7759/cureus.41476
Wiehle R, et al. Testosterone Restoration by Enclomiphene Citrate in Men with Secondary Hypogonadism: Pharmacodynamics and Pharmacokinetics. BJU Int. 2013;112(8):1188–1200. doi:10.1111/bju.12363

Product Disclaimer

This information is for educational purposes only.

This compounded product has not been reviewed, approved, or evaluated by the Food and Drug Administration for safety and effectiveness. This product is not intended to diagnose, treat, cure, or prevent any disease. No claims are made regarding treatment, cure, or prevention of any disease or condition.

This information is a summary. It may not cover all possible drug information about this product. For complete product information, refer to the manufacturer’s prescribing information and labeling. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A WP Pharma Labs pharmacist will be happy to answer any questions. For consultation, please call 1-800-441-0048.

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