Sermorelin

(Ship Cold) Injection

3 mg/mL

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Disclaimer: Images are for reference only; actual products may vary.

Product Overview Coming Soon

Product Overview

Product Description

Sermorelin Description^1-6

Sermorelin is a synthetic peptide analog of the body’s natural growth hormone–releasing hormone (GHRH), composed of the first 29 amino acids of the native 44–amino acid human GHRH. It is used as a diagnostic agent and as a growth hormone secretagogue to stimulate the pituitary gland’s endogenous production of human growth hormone (hGH). Sermorelin is most commonly administered by subcutaneous injection.

References

Walker RF. Sermorelin: a better approach to management of adult-onset growth hormone insufficiency? Clin Interv Aging. 2006;1(4):307-8. doi: 10.2147/ciia.2006.1.4.307. PMID: 18046908; PMCID: PMC2699646.
RxList. Sermorelin Acetate Injection. https://www.rxlist.com/sermorelin-acetate-drug.htm
Bianco AC, et al. “Physiology of the GHRH–GH–IGF1 axis.” Endocr Rev. 2002;23(1):38–89.
Drugs.com. Sermorelin Acetate; accesses June 27 2025; https://www.drugs.com/cdi/sermorelin-acetate.html
Walker RF. “Clinical utility of growth hormone-releasing peptides.” Drugs. 1994;47(2):269-273. PubMed PMID: 7517376
Geref Description Archive.(discontinued product); accessed June 26 2025; https://worldhealth.net/news/geref_seristim/

Product Mechanism of Action

Mechanism of Action^1-6

Sermorelin acts as an agonist at the GHRH receptor in the anterior pituitary, stimulating somatotroph cells to increase the synthesis and pulsatile release of endogenous growth hormone (GH). This in turn stimulates the liver to produce insulin-like growth factor-1 (IGF-1), which mediates many of the anabolic and metabolic effects associated with human growth hormone.

Unlike exogenous recombinant human growth hormone (rhGH), sermorelin stimulates physiologic GH production while preserving feedback regulation via somatostatin and IGF-1 pathways. This supports a more natural circadian rhythm of GH release.

Product Adverse Reactions

Common^1-6

Injection site reactions (pain, redness, swelling)
Facial flushing
Headache
Nausea
Dizziness
Sleep disturbances (insomnia or drowsiness)

Product Contraindications & Precautions

Contraindications^1-6

Hypersensitivity to sermorelin or any component of the formulation
Active malignancies, particularly those influenced by GH or IGF-1
Intracranial lesion
Use during pregnancy and breastfeeding (due to insufficient safety data)

Precautions^1-6

Use with caution in patients with a history of cancer or intracranial lesions
May unmask latent diabetes mellitus due to its GH-stimulating properties

Product Storage

Store refrigerated at 2°C to 8°C (36°F to 46°F); protect from light.
After reconstitution: Store refrigerated and discard remainder 28 days after mixing.
Do not freeze. Discard if solution becomes cloudy or discolored.

Product References

Walker RF. Sermorelin: a better approach to management of adult-onset growth hormone insufficiency? Clin Interv Aging. 2006;1(4):307-8. doi: 10.2147/ciia.2006.1.4.307. PMID: 18046908; PMCID: PMC2699646.
RxList. Sermorelin Acetate Injection. https://www.rxlist.com/sermorelin-acetate-drug.htm
Bianco AC, et al. “Physiology of the GHRH–GH–IGF1 axis.” Endocr Rev. 2002;23(1):38–89.
Drugs.com. Sermorelin Acetate; accesses June 27 2025; https://www.drugs.com/cdi/sermorelin-acetate.html
Walker RF. “Clinical utility of growth hormone-releasing peptides.” Drugs. 1994;47(2):269-273. PubMed PMID: 7517376
Geref Description Archive.(discontinued product); accessed June 26 2025; https://worldhealth.net/news/geref_seristim/

Product Disclaimer

This information is for educational purposes only.

This compounded product has not been reviewed, approved, or evaluated by the Food and Drug Administration for safety and effectiveness. This product is not intended to diagnose, treat, cure, or prevent any disease. No claims are made regarding treatment, cure, or prevention of any disease or condition.

This information is a summary. It may not cover all possible drug information about this product. For complete product information, refer to the manufacturer’s prescribing information and labeling. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A WP Pharma Labs pharmacist will be happy to answer any questions. For consultation, please call 1-800-441-0048.

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