(Commercial Product) Tablets
20 mg
Product Overview
Tamoxifen Citrate Description1,2,3
Tamoxifen is an oral selective estrogen receptor modulator (SERM) that was approved in the 1970s. It exhibits both estrogenic and antiestrogenic effects depending on the target tissue. Tamoxifen acts as a competitive inhibitor of estrogen at estrogen receptors in breast tissue. By blocking estrogen activity at these receptors, it can reduce the growth of estrogen-dependent breast tumors.
In females, tamoxifen is used for:
Adjuvant treatment of breast cancer and treatment of metastatic breast cancer
Reduction of the risk of invasive breast cancer in women with ductal carcinoma in situ (DCIS) following surgery and radiation
Reduction of breast cancer risk in women considered to be at high risk
In males, tamoxifen’s SERM activity is used to alter the balance between estrogen and testosterone in hypogonadism, supporting endogenous testosterone production in the testes.
Mechanism of Action3
In females, tamoxifen decreases estrogen binding to estrogen-dependent breast tissue. This activity of tamoxifen decreases the growth of estrogen-dependent breast tumors and on a molecular level, the inhibition of the expression of estrogen-dependent genes (RNA transcription). Tamoxifen’s activity results in reduced DNA polymerase activity, impaired thymidine utilization, blockade of estradiol uptake, and decreased estrogen response. Tamoxifen’s activity is cytostatic and occurs in the G2 phase. Tamoxifen also inhibits other factors involved in cancer growth, including insulin-like growth factor type 1 (IGF-1) and transforming growth factor-beta (TGF-beta).1,2 In males, tamoxifen works as an estrogen antagonist in the hypothalamus and pituitary gland to inhibit negative feedback from estrogen. This negative feedback allows for release of LH and FSH which results in the production of testosterone and spermatogenesis.
Common1,2
Contraindications1,2
Precautions1,2
WPPL operates as a 503A compounding pharmacy and prepares individualized prescription medications pursuant to provider direction. Compounded preparations are not reviewed, tested, or approved by the FDA.
This listing also includes commercially manufactured products for convenience; these items are not compounded by our pharmacy and are sold as provided by their manufacturers. Actual products in stock at time of dispensing may vary due to supply chain variability. Any statements regarding non-compounded products are manufacturer-supplied, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. WPPL does not verify or endorse any therapeutic claims made by manufacturers. Please refer to original labeling for complete product information.
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