Chewable Tablets
25 mg
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Product Overview
Tadalafil Chewable Tablets Description1,2
Tadalafil is a phosphodiesterase type 5 (PDE5) inhibitor with an average terminal half-life exceeding 17 hours. This duration is significantly longer than that of other PDE5 inhibitors, such as sildenafil and vardenafil. The extended half-life supports both once-daily and on-demand dosing options. Tadalafil is indicated for the treatment of pulmonary arterial hypertension (PAH), erectile dysfunction (ED), benign prostatic hypertrophy (BPH), or the combined management of ED and BPH.
References
Mechanism of Action1,2,3
Phosphodiesterase (PDE) has many isoforms and is an enzyme that has many functions in the body including degrading the effect of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). PDE5 is an enzyme that is found in many parts of the body including in the smooth muscle of the corpus cavernosum, prostate, bladder, the vascular and visceral smooth muscle, skeletal muscle, urethra, platelets, kidney, lung, cerebellum, heart, liver, testis, seminal vesicle, and pancreas. Tadalafil is a selective inhibitor of PDE5, the enzyme responsible for the degradation of cGMP. The drug has selective activity on PDE5 than other phosphodiesterase isoforms. Tadalafil activity on PDE5 is more than 10,000-fold more than for PDE1, PDE2, PDE4, and PDE7 enzymes. Increased cGMP leads to smooth muscle relaxation in the corpus cavernosum which can help in maintaining an erection.
Common1
Contraindications1,2
Precautions1,2
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