Cream
2% / 3% / 6%
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Product Overview
Sildenafil / Aminophylline / Arginine Description1-9
Compounded Sildenafil_Aminophylline_Arginine Cream is a topical formulation intended to support female sexual arousal and genital sensitivity. It contains three active ingredients: sildenafil, aminophylline (a phosphodiesterase inhibitor), and L-arginine (a nitric oxide precursor). This combination may help improve blood flow to the genital tissues. The cream is typically applied to the vulvar or clitoral area before sexual activity to promote arousal, enhance lubrication, and support orgasmic response in women experiencing Female Sexual Arousal Disorder (FSAD) or other sexual dysfunctions.
Sildenafil1-5
Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor with a half-life of approximately 4 hours. It is clinically used to treat erectile dysfunction and pulmonary hypertension. Research indicates it may also support female sexual arousal. Due to its half-life, oral sildenafil is typically used “on-demand” before sexual activity.
Aminophylline6,7
Aminophylline is a complex of theophylline and ethylenediamine, which improves its solubility. Historically, aminophylline has been used for asthma, chronic obstructive pulmonary disease, and apnea of prematurity. It is thought to have vasodilatory activity and may also exert cardiac and diuretic effects. Its actions in the body may include inhibition of type III or IV phosphodiesterase (PDE), increasing calcium ion concentration in smooth muscle, inhibiting histamine release, and antagonizing adenosine.
Arginine8,9
L-Arginine is an essential amino acid converted in the body to nitric oxide, a potent vasodilator and neurotransmitter. It is naturally present in red meat, poultry, fish, and dairy, and also supports protein synthesis, immune function, and wound healing.
References
Sildenafil1-4
Phosphodiesterase (PDE) has many isoforms and is an enzyme that has many functions in the body including degrading the effect of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). PDE5 is an enzyme that is found in many parts of the body including in the smooth muscle of the corpus cavernosum, prostate, bladder, the vascular and visceral smooth muscle, skeletal muscle, urethra, platelets, kidney, lung, cerebellum, heart, liver, testis, seminal vesicle, and pancreas. Sildenafil is structurally similar to cGMP and prevents degradation of cGMP by competitively binding and inhibiting activity of PDE5. When PDE5 is inhibited, cGMP accumulates and leads to smooth muscle relaxation. Studies have shown that sildenafil facilitates the relaxation of the clitoral corpus cavernosum through the nitric oxide-cGMP pathway. This may improve genital blood flow and vaginal engorgement.
Aminophylline6,7
Phosphodiesterase activity-Inhibits phosphodiesterase (PDE), leading to increased intracellular cyclic AMP (cAMP) levels. Elevated cAMP may promote smooth muscle relaxation and vasodilation, improving blood flow to applied areas.
Nonselective adenosine receptor antagonist-It acts on A1, A2, and A3 receptors with similar affinity which may explain the drug’s cardiac effects. Adenosine-mediated channels also increase the contraction force of diaphragmatic muscles by enhancing their calcium uptake.
Arginine8,9
L-Arginine is necessary for making proteins and is commonly used to promote circulation. The body converts arginine to nitric oxide (NO) through the action of nitric oxide synthase which may relax blood vessels, allowing blood to flow.
Adverse Reactions5,7,8,9
Common (topically)
Rare
Oral (sildenafil)
Contraindications5,7,8,9
Precautions5,7,8,9
Store at 20–25°C (68–77°F). Protect from excessive heat, light, and moisture.
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