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Product Overview
Sildenafil Description1,2
Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor with a half-life of approximately 4 hours. Clinically, it is used to treat erectile dysfunction and pulmonary hypertension. Due to its half-life, it is typically used “on-demand” prior to sexual activity.
References
Mechanism of Action1,2,3
Phosphodiesterase (PDE) has many isoforms and is an enzyme that has many functions in the body including degrading the effect of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). PDE5 is an enzyme that is found in many parts of the body including in the smooth muscle of the corpus cavernosum, prostate, bladder, the vascular and visceral smooth muscle, skeletal muscle, urethra, platelets, kidney, lung, cerebellum, heart, liver, testis, seminal vesicle, and pancreas. Sildenafil is structurally similar to cGMP and prevents degradation of cGMP by competitively binding and inhibiting activity of PDE5. When PDE5 is inhibited, cGMP accumulates and leads to smooth muscle relaxation. In the corpus cavernosum, this leads to penile erection. In the pulmonary system, it leads to vasodilation in the pulmonary arteries.
Common1,2
Contraindications1,2
Precautions1,2
Store at 20–25°C (68–77°F). Protect from excessive heat, light, and moisture.
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