(Ship Cold) Gel-Troche
50 mg | 100 mg
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Product Overview
Sildenafil Gel-Troche Description1,2
Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor with an approximate half-life of four hours. Clinically, it is used in the management of erectile dysfunction and pulmonary hypertension. Due to its half-life, sildenafil is typically administered on an on-demand basis prior to sexual activity.
References
Mechanism of Action1,2,3
Phosphodiesterase (PDE) has many isoforms and is an enzyme that has many functions in the body including degrading the effect of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). PDE5 is an enzyme that is found in many parts of the body including in the smooth muscle of the corpus cavernosum, prostate, bladder, the vascular and visceral smooth muscle, skeletal muscle, urethra, platelets, kidney, lung, cerebellum, heart, liver, testis, seminal vesicle, and pancreas. Sildenafil is structurally similar to cGMP and prevents degradation of cGMP by competitively binding and inhibiting activity of PDE5. When PDE5 is inhibited, cGMP accumulates and leads to smooth muscle relaxation. In the corpus cavernosum, this leads to penile erection. In the pulmonary system, it leads to vasodilation in the pulmonary arteries.
Common1,2
Contraindications1,2
Precautions1,2
Use with caution in patients with:
Store at controlled room temperature 20–25°C (68–77°F) or may be stored in the refrigerator. Keep in a dry place. Protect from light, heat, and moisture. Keep out of reach of children and pets.
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