Semaglutide / Niacinamide

(Ship Cold) Injection

2.5 mg / 2 mg / mL

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Product Overview

Semaglutide1-4

Semaglutide is a synthetic glucagon-like peptide-1 receptor agonist (GLP-1 RA) and functions as an incretin mimetic. Incretins are hormones released from the gastrointestinal tract into systemic circulation and are involved in glycemic regulation. Semaglutide is used for the following indications:

  • Management of type 2 diabetes mellitus as an adjunct to diet and exercise.
  • Reduction in the risk of major adverse cardiovascular events, including cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke, in individuals with established cardiovascular disease and type 2 diabetes mellitus, chronic kidney disease and type 2 diabetes mellitus, or established cardiovascular disease with obesity or overweight.
  • Treatment of obesity and chronic weight management as an adjunct to a reduced-calorie diet and increased physical activity.
  • Treatment of metabolic dysfunction-associated steatotic liver disease† (MASLD) or metabolic dysfunction-associated steatohepatitis† (MASH) in individuals with type 2 diabetes mellitus.

Niacinamide(vitamin B3)5-7

Niacinamide, also referred to as niacin or nicotinic acid, is a form of vitamin B3 and an essential nutrient. It is present in foods such as bran, yeast, eggs, peanuts, poultry, red meat, fish, whole-grain cereals, legumes, and seeds. Niacinamide is involved in the conversion of food into energy and contributes to protection against oxidative stress by regulating oxidative enzymes and acting as an antioxidant. It is used in the management of dermatological conditions, central nervous system disorders, and elevated cholesterol levels.

Semaglutide 1-4

Semaglutide is an incretin mimetic that works on the glucagon-like peptide-1 (GLP-1) receptor by binding and activating the GLP-1 receptor. It has 94% sequence homology to human GLP-1. GLP-1 medications regulate glucose metabolism after oral consumption of carbohydrates and fats. The drug increases insulin secretion by glucose-dependent insulin synthesis and in vivo secretion of insulin from pancreatic beta cells in the presence of elevated glucose levels. It also suppresses glucagon secretion, slows gastric emptying, reduces food intake, and promotes beta-cell proliferation.  

Niacinamide(vitamin B3)5-7

Niacinamide contributes to supporting mitochondrial function and metabolic pathways through its conversion to NAD⁺/NADP⁺.It is a vital component in the oxidized state of nicotinamide adenine dinucleotide (NAD, or coenzyme 1) and the reduced form of nicotinamide adenine dinucleotide phosphate (NADP, or coenzyme 2). The coenzymes, NAD and NADP) facilitate essential oxidation-reduction reactions. These coenzymes play key roles in glycolysis, pyruvate metabolism, protein and amino acid metabolism, pentose biosynthesis, glycerol metabolism, synthesis of high-energy phosphate bonds, and fatty acid metabolism.

Common 1-3

Most adverse reactions are gastrointestinal in nature and dose-dependent:

  • Gastrointestinal: Nausea, vomiting, diarrhea, constipation, dyspepsia, decreased appetite, abdominal pain
  • Headache, dizziness, and injection site reactions

Contraindications1-3

  • Hypersensitivity to semaglutide or glycine or its components
  • In people with a personal or family history of medullary thyroid carcinoma (MTC) or in people with multiple endocrine neoplasia syndrome type 2
  • In patients who are pregnant

Precautions1-3

  • In patients with a history of pancreatitis and gall bladder disease
  • In patients with renal and hepatic impairment

Refrigerate at 2–8°C (36–46°F) before and during use. Do not freeze. Protect from light and excessive heat.

  1. Semaglutide (Ozempic) Prescribing Information – Novo Nordisk https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209637lbl.pdf. Revised December 2017. Accessed May 27, 2025
  2. Semaglutide (Wegovy) Prescribing Information Novo Nordisk www.accessdata.fda.gov/drugsatfda_docs/label/2023/215256s007lbl.pdf. Revised July 2023. Accessed June 22, 2025
  3. Clinical Pharmacology semaglutide clinical monograph 2025 https://www.clinicalkey.com/pharmacology/   
  4. Knudsen LB, Lau J. The Discovery and Development of Liraglutide and Semaglutide. Front Endocrinol (Lausanne). 2019 Apr 12;10:155.
  5. Niacinamide – Professional Monograph; NatMed Pro ; 2025 ; https://naturalmedicines.therapeuticresearch.com/Data/ProMonographs/Niacinamide
  6. Vitamin B3 StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK526107/  February 29, 2024. Accessed June 26, 2025
  7. Clinical Pharmacology powered by Elsevier (ClinicalKey) – Niacinamide Monograph. https://www.clinicalkey.com

WPPL operates as a 503A compounding pharmacy and prepares individualized prescription medications pursuant to provider direction. Compounded preparations are not reviewed, tested, or approved by the FDA.

This listing also includes commercially manufactured products for convenience; these items are not compounded by our pharmacy and are sold as provided by their manufacturers. Actual products in stock at time of dispensing may vary due to supply chain variability. Any statements regarding non-compounded products are manufacturer-supplied, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. WPPL does not verify or endorse any therapeutic claims made by manufacturers. Please refer to original labeling for complete product information.

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