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MI B Complex B2 B3 B5

MI / B-Complex (B2, B3, B5) / Chromium / Carnitine

(Trimtropic II) Injection

20 mg / 40 mg / 5 mg / 33 mg / 2 mg / 25 mcg / 25 mg / mL

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Product Overview

MI / B-Complex (B2, B3, B5) / Chromium / Carnitine (Trimtropic II) Description1-10

Trimtropic II is a formulation that combines the ingredients listed below and is intended to support weight management when used in conjunction with appropriate nutrition, dietary choices, and exercise programs.

  • Methionine: An essential sulfur-containing amino acid involved in protein synthesis and methylation pathways.

  • Inositol: A sugar alcohol structurally related to glucose that plays a role in cell signaling and insulin responsiveness.

  • Riboflavin (Vitamin B₂): A water-soluble vitamin required for oxidative energy metabolism and proper enzyme activity.

  • Niacinamide (Vitamin B₃): The amide form of niacin that supports cellular energy production and redox reactions as a component of NAD and NADP coenzymes.

  • Pantothenic Acid (Vitamin B₅): A vitamin necessary for the synthesis of coenzyme A and the metabolism of fatty acids.

  • Methylcobalamin (Vitamin B₁₂): The active form of vitamin B₁₂, essential for methylation processes, nervous system function, and red blood cell formation.

  • Chromium Picolinate: A trace mineral complex with evidence supporting a role in insulin activity and glucose metabolism.

  • L-Carnitine: An amino acid derivative that facilitates the transport of fatty acids into mitochondria for oxidation and is present in high concentrations in skeletal and cardiac muscle.

References

  1. Medlineplus- Methionine; Accessed June 14, 2025, through: https://medlineplus.gov/druginfo/natural/875.html
  2. Methionine – Professional Monograph; NatMed Pro; 2025; https://naturalmedicines.therapeuticresearch.com/Data/ProMonographs/Methionine 
  3. NIH Monograph – Inositol; Accessed June 14, 2025, through: https://ods.od.nih.gov/factsheets/MyoInositol-HealthProfessional/
  4. Inositol – Professional Monograph; NatMed Pro; 2025; https://naturalmedicines.therapeuticresearch.com/Data/ProMonographs/Inositol 
  5. NIH Monograph – Riboflavin; Accessed June 14, 2025, through: https://ods.od.nih.gov/factsheets/Riboflavin-HealthProfessional/
  6. NIH Monograph – Niacinamide; Accessed June 14, 2025, through: https://ods.od.nih.gov/factsheets/Niacin-HealthProfessional/
  7. NIH Monograph – Pantothenic Acid; Accessed June 14, 2025, through: https://ods.od.nih.gov/factsheets/PantothenicAcid-HealthProfessional/
  8. NIH Monograph – Vitamin B12; Accessed June 14, 2025, through: https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/
  9. NIH Monograph – Chromium; Accessed June 14, 2025, through: https://ods.od.nih.gov/factsheets/Chromium-HealthProfessional/
  10. NIH Monograph – L-Carnitine; Accessed June 14, 2025, through: https://ods.od.nih.gov/factsheets/Carnitine-HealthProfessional

Mechanism of Action1-10

Methionine- Supports methylation reactions and may assist in lipid metabolism; methionine restriction is associated with improved metabolic markers in some models.

Inositol- May improve insulin signaling via phosphatidylinositol pathways; explored in PCOS and metabolic syndrome.

Riboflavin (B₂)- Cofactor in flavoprotein enzymes (FAD, FMN) involved in carbohydrate, fat, and protein metabolism.

Niacinamide (B₃)- Provides NAD/NADP for redox reactions critical to ATP production and lipid metabolism.

Pantothenic Acid- Integral for CoA and acyl-carrier proteins, enabling fatty acid oxidation and biosynthesis.

Methylcobalamin (B12)- Supports homocysteine remethylation and DNA synthesis; assists in energy conversion indirectly.

Chromium Picolinate- May enhance insulin receptor sensitivity and carbohydrate metabolism.

L-Carnitine- Transports long-chain fatty acids across mitochondrial membranes for beta-oxidation (energy production).

Common 1-10

Methionine- Possible increase in homocysteine levels; rare GI discomfort or headaches.

Inositol- Generally well tolerated; high doses may cause nausea, bloating, dizziness, or fatigue.

Riboflavin (B₂)- Generally safe; may cause bright yellow urine.

Niacinamide (B₃)- High doses may cause flushing (less so than niacin), nausea, or elevated liver enzymes.

Pantothenic Acid- Mild GI upset or diarrhea at high doses.

Methylcobalamin (B12)- Injection site soreness, rare diarrhea or skin rash.

Chromium Picolinate- Headache, dizziness, nausea; high doses may affect kidney or liver function.

L-Carnitine- Nausea, vomiting, diarrhea; insomnia and restlessness reported with higher doses.

Methionine- Use caution in cardiovascular disease, hyperhomocysteinemia, or hepatic impairment.

Contraindications & Precautions 1-10

Inositol- Monitor use in those with bipolar disorder or insulin therapy; consult physician.

Riboflavin (B₂)- No known major contraindications; generally safe in most populations.

Niacinamide (B₃)- Caution in liver disease or diabetes; monitor liver enzymes.

Pantothenic Acid- Generally safe; rare hypersensitivity reactions have been reported.

Methylcobalamin- Avoid in hereditary optic neuropathy (Leber’s disease); monitor for polycythemia.

Chromium Picolinate- Avoid in patients with renal or hepatic impairment; caution with concurrent NSAIDs or corticosteroids.

L-Carnitine- Avoid or closely monitor in seizure disorders and end-stage renal disease; not recommended during pregnancy without supervision.

Store at room temperature; protect from light moisture and heat. DO NOT REFRIGERATE.

  1. Medlineplus- Methionine; Accessed June 14, 2025, through: https://medlineplus.gov/druginfo/natural/875.html
  2. Methionine – Professional Monograph; NatMed Pro; 2025; https://naturalmedicines.therapeuticresearch.com/Data/ProMonographs/Methionine 
  3. NIH Monograph – Inositol; Accessed June 14, 2025, through: https://ods.od.nih.gov/factsheets/MyoInositol-HealthProfessional/
  4. Inositol – Professional Monograph; NatMed Pro; 2025; https://naturalmedicines.therapeuticresearch.com/Data/ProMonographs/Inositol 
  5. NIH Monograph – Riboflavin; Accessed June 14, 2025, through: https://ods.od.nih.gov/factsheets/Riboflavin-HealthProfessional/
  6. NIH Monograph – Niacinamide; Accessed June 14, 2025, through: https://ods.od.nih.gov/factsheets/Niacin-HealthProfessional/
  7. NIH Monograph – Pantothenic Acid; Accessed June 14, 2025, through: https://ods.od.nih.gov/factsheets/PantothenicAcid-HealthProfessional/
  8. NIH Monograph – Vitamin B12; Accessed June 14, 2025, through: https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/
  9. NIH Monograph – Chromium; Accessed June 14, 2025, through: https://ods.od.nih.gov/factsheets/Chromium-HealthProfessional/
  10. NIH Monograph – L-Carnitine; Accessed June 14, 2025, through: https://ods.od.nih.gov/factsheets/Carnitine-HealthProfessional
This information is for educational purposes only.
This compounded product has not been reviewed, approved, or evaluated by the Food and Drug Administration for safety and effectiveness. This product is not intended to diagnose, treat, cure, or prevent any disease. No claims are made regarding treatment, cure, or prevention of any disease or condition.
This information is a summary. It may not cover all possible drug information about this product. For complete product information, refer to the manufacturer’s prescribing information and labeling. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A WP Pharma Labs pharmacist will be happy to answer any questions. For consultation, please call 1-800-441-0048.

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