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Cyanocobalamin

Cyanocobalamin (B12)

(Commercial Product) Injection

1,000 mcg/mL

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Disclaimer: Images are for reference only; actual products may vary.

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Product Overview

Cyanocobalamin (B12) Description1

Cyanocobalamin is a synthetic form of vitamin B12 that supports multiple methylation reactions in the body. It is required for growth, cell replication, hematopoiesis, and the synthesis of nucleoproteins and myelin. Tissues with rapid cellular turnover, such as epithelial tissue, bone marrow, and myeloid cells, have the highest demand for cyanocobalamin.

Cyanocobalamin has numerous approved indications, many of which involve conditions that result in cyanocobalamin deficiency due to impaired absorption, including:

  • Pernicious anemia
  • Malabsorption
  • Atrophic gastritis
  • Long-term metformin use
  • Chronic acid-reducing medication use
  • Small bowel bacteria overgrowth
  • Total or partial gastrectomy
  • Diphyllobothrium latum infection
  • Helicobacter pylori infection
  • Pancreatic insufficiency
  • Malignancy of the pancreas or bowel
  • Dietary deficiency of vitamin B12
  • Transcobalamin II deficiency

Cyanocobalamin can be administered via intramuscular (IM) or subcutaneous (SC) routes.

References

  1. Vasavada A, Patel P, Sanghavi DK. Cyanocobalamin. StatPearls. January 31. 2024. Accessed August 10, 2025. https://www.ncbi.nlm.nih.gov/books/NBK555964/

Mechanism of Action1-3

Vitamin B12 is important for division and growth of the cell. It is converted to coenzyme B12 in the body and in this form facilitates the conversion of homocysteine to methionine (methylcobalamin) and plays an important role in converting methylmalonyl-coenzyme A to succinyl-Co-A (fatty acid and amino acid metabolism). Without coenzyme B12, tetrahydrofolate cannot be produced from 5-methyl tetrahydrofolate leading to folate deficiency. In addition, vitamin B12 is needed to produce myelin and is important for axon and nerve development. Gastrointestinal absorption of vitamin B12 depends on the presence of sufficient intrinsic factor and calcium ions.

Common1-3

  • Pruritus, transitory rash and a feeling of swelling (edema) of the entire body
  • Pain or redness at injection site
  • Headache

Contraindications1-3

  • Hypersensitivity or intolerance to cyanocobalamin or cobalt or its excipients
  • Aluminum; toxic aluminum concentrations may be seen with high doses, prolonged use, or renal dysfunction

Precautions1-3

  • Monitor for hypokalemia, after initial treatment, an increased red blood cell production may occur which may lower serum potassium levels
  • Use with caution in individuals with polycythemia vera or renal disease .

Store at 20°C to 25°C (68°F to 77°F). Do not freeze. Protect from light and moisture. Keep in original packaging and out of reach of children.

  1. Vasavada A, Patel P, Sanghavi DK. Cyanocobalamin. StatPearls. January 31. 2024. Accessed August 10, 2025. https://www.ncbi.nlm.nih.gov/books/NBK555964/
  2. Clinical Pharmacology Cyanocobalamin clinical monograph 2025 https://www.clinicalkey.com/pharmacology/ 
  3. Cyanocobalamin package insert. American Reagent January 2021. https://www.americanregent.com/media/3187/cyanocobalamin-insert-in0031-rev-1-2021.pdf Accessed August 10, 2025.
This information is for educational purposes only.
WP Pharma Labs distributes certain FDA-approved commercial products that are manufactured by third-party pharmaceutical companies. These products are not compounded or manufactured by WP Pharma Labs. Product availability at the time of dispensing may vary due to supply chain conditions.
This information is a summary. It may not cover all possible drug information about this product. For complete product information, refer to the manufacturer’s prescribing information and labeling. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A WP Pharma Labs pharmacist will be happy to answer any questions. For consultation, please call 1-800-441-0048.

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