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NAD+ compounding

NAD+

Lyophilized Vial

1 gm/Vial

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Disclaimer: Images are for reference only; actual products may vary.

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Product Overview

NAD+ Description1-6

Nicotinamide Adenine Dinucleotide (NAD⁺) is essential for metabolic function in the body, participating in more than 500 enzymatic reactions that support overall health. NAD⁺ plays a key role in energy metabolism, mitochondrial homeostasis, and processes related to cellular survival and death. It also serves as a mediator of important cellular functions, including DNA maintenance and repair. NAD⁺ levels naturally decline with age. Restoring NAD⁺ levels may help improve altered metabolic processes, reduce susceptibility to disease, and support longevity.

Potential benefits associated with increasing NAD⁺ levels include:

  • Improved cognitive function
  • Protection of brain tissue from neurodegenerative processes
  • Enhanced vascularization of blood vessels
  • Reduction in hepatic steatosis
  • Improved muscle strength and pancreatic function, including increased insulin secretion
  • Decreased inflammation

References

  1. https://www.nad.com/what-is-nad
  2. Hwang ES, Song SB. Possible Adverse Effects of High-Dose Nicotinamide: Mechanisms and Safety Assessment. Biomolecules. 2020 Apr 29;10(5):687.
  3. Covarrubias AJ, Perrone R, Grozio A, Verdin E. NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. 2021 Feb;22(2):119-141.
  4. Xie N, Zhang L, Gao W, Huang C, Huber PE, Zhou X, Li C, Shen G, Zou B. NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential. Signal Transduct Target Ther. 2020 Oct 7;5(1):227.
  5. Mark, J. The Vital Role of NAD in Cellular Metabolism and Aging https://www.therealgutdoctor.com/the-vital-role-of-nad-in-cellular-metabolism-and-aging/. August 13, 2024. Accessed June 29, 2025
  6. Lopez J NAD IV Therapy Side Effects: Exploring the Potential Risks. https://www.azivmedics.com/side-effects-of-nad-therapy July 6, 2023. Accessed June 30, 2025.

Mechanism of Action1-6

NAD+ is critical for metabolism and physiological function. It accepts electrons during metabolic reactions to become NADH (reduced form). NADH uses the electron to donate ot other molecules. This is important for ATP production in the body. This process occurs during glycolysis, fatty acid oxidation, and the TCA cycle. There is a continuous conversion of NAD+ to NADH in cells in the body which is critical for energy flow. NAD+ is also important for sirtuin regulation (DNA repair, inflammation processes, and fat metabolism). It is a substrate for  PARPs (poly (ADP-ribose) polymerases) (repair of damaged DNA), is important to prevent neurodegenerative processes.

Common2,6

  • Flushing, warm sensation
  • Headache, dizziness, lightheadedness
  • Nausea, abdominal cramping

Contraindications2,6

  • Known hypersensitivity to NAD+ or any component of the solution
  • Active infection or inflammation

Precautions2,6

  • Patients should be monitored during and after administration for tolerance

Store at 2°C to 8°C (36°F to 46°F); Protect from light, heat, and moisture.

  1. https://www.nad.com/what-is-nad
  2. Hwang ES, Song SB. Possible Adverse Effects of High-Dose Nicotinamide: Mechanisms and Safety Assessment. Biomolecules. 2020 Apr 29;10(5):687.
  3. Covarrubias AJ, Perrone R, Grozio A, Verdin E. NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. 2021 Feb;22(2):119-141.
  4. Xie N, Zhang L, Gao W, Huang C, Huber PE, Zhou X, Li C, Shen G, Zou B. NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential. Signal Transduct Target Ther. 2020 Oct 7;5(1):227.
  5. Mark, J. The Vital Role of NAD in Cellular Metabolism and Aging https://www.therealgutdoctor.com/the-vital-role-of-nad-in-cellular-metabolism-and-aging/. August 13, 2024. Accessed June 29, 2025
  6. Lopez J NAD IV Therapy Side Effects: Exploring the Potential Risks. https://www.azivmedics.com/side-effects-of-nad-therapy July 6, 2023. Accessed June 30, 2025.
This information is for educational purposes only.
This compounded product has not been reviewed, approved, or evaluated by the Food and Drug Administration for safety and effectiveness. This product is not intended to diagnose, treat, cure, or prevent any disease. No claims are made regarding treatment, cure, or prevention of any disease or condition.
This information is a summary. It may not cover all possible drug information about this product. For complete product information, refer to the manufacturer’s prescribing information and labeling. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A WP Pharma Labs pharmacist will be happy to answer any questions. For consultation, please call 1-800-441-0048.

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