Capsule
4.5 mcg / 19 mcg | 9 mcg / 38 mcg
13.5 mcg / 57 mcg | 18 mcg / 76 mcg
22.5 mcg / 95 mcg | 27 mcg / 114 mcg
50 mcg / 12.5 mcg
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Product Overview
T3/T4 Oral Formulation Description1,2
The T3/T4 combination is an oral compounded formulation that may be prepared as either an immediate-release or sustained-release dosage form. T3 acts in a manner comparable to the naturally occurring thyroid hormone triiodothyronine. It is available as an oral capsule and is intended for use as replacement or adjunctive therapy in the management of hypothyroidism.
The human body produces two primary thyroid hormones: triiodothyronine (T3), also known as liothyronine, and thyroxine (T4), also referred to as levothyroxine. Triiodothyronine is the more biologically active hormone. Within the body, T4 is converted into T3. Additionally, T3 has a more rapid onset of action than T4 and may be utilized in individuals who have limited conversion of T4 to T3.
The combination of T3 and T4 is indicated for use in the following:
Hypothyroidism: As replacement therapy in primary (thyroidal), secondary (pituitary), or tertiary (hypothalamic) congenital or acquired hypothyroidism.
References
Mechanism of Action1-3
3 and T4 release from the thyroid gland is regulated by thyroid stimulating hormone (TSH) which is secreted by the anterior pituitary gland. The release of TSH from the anterior pituitary gland is controlled by the blood levels of T3 and T4. As blood levels of T3 and T4 decrease TSH secretion from the anterior pituitary gland increases. This feedback mechanism helps to manage the levels of T3 and T4 in the body. In the body, T4 is converted into T3
Triiodothyronine (T3) exerts its physiologic actions through control of DNA transcription and protein synthesis. It does this by entering the cell nucleus and binding to thyroid receptor proteins attached to DNA. This hormone nuclear receptor complex activates gene transcription and synthesis of messenger RNA and cytoplasmic proteins. The physiological actions of thyroid hormones are produced predominantly by T3.
Common (mimic symptoms of hyperthyroidism)1,2
Contraindications1
Precautions1
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