Lotion
5% / 2% / 0.003% / 0.1%
Product Overview
The following drugs have been combined into a lotion for the treatment of hair loss.
Minoxidil1-17
Topical minoxidil is a vasodilator initially developed as an oral antihypertensive agent. Hair growth stimulation was observed as a side effect (hypertrichosis, or excessive abnormal hair growth) in patients taking oral minoxidil. Based on these observations, minoxidil was subsequently FDA-approved for androgenetic alopecia in both men and women.
Ketoconazole1-17
Ketoconazole is a synthetic imidazole antifungal commonly used in both topical and oral formulations. Topically, ketoconazole has been used to promote hair growth, particularly in androgenetic alopecia and hair loss associated with seborrheic dermatitis. It is often compounded into shampoos, foams, or lotions, either alone or in combination with agents such as minoxidil or finasteride to enhance effectiveness.
Latanoprost1-17
Latanoprost is a prostaglandin F2α (PGF2α) analog primarily used to treat open-angle glaucoma and ocular hypertension. Evidence suggests that latanoprost can promote hair growth, particularly in androgenetic alopecia and in eyelash or eyebrow hypotrichosis. Its hair regrowth potential was first noted due to the side effect of increased eyelash growth in patients treated for glaucoma.
Finasteride1-17
Finasteride is a 5-alpha reductase inhibitor that has been shown to benefit men with symptomatic benign prostatic hyperplasia, a condition affecting men over the age of 50. Finasteride is also used in the management of androgenetic alopecia (male pattern hair loss).
Mechanism of Action1-7,10-17
Minoxidil
The drug has many mechanisms in supporting hair growth:
Ketoconazole
Mechanism of Action (in Hair Loss)
Antifungal Action:
Inhibits ergosterol synthesis, a critical component of fungal cell membranes, effectively treating Malassezia spp. overgrowth often seen in seborrheic dermatitis, which is linked to scalp inflammation and hair loss.
Anti-Androgenic Activity (indirect):Though not a systemic anti-androgen, ketoconazole may locally inhibit 5α-reductase, reducing dihydrotestosterone (DHT) formation in the scalp—a key factor in androgenetic alopecia.
Anti-Inflammatory Properties:
Reduces local scalp inflammation, which is a contributing factor in various forms of alopecia, including telogen effluvium and AGA.
Cleansing and Scalp Health:
Improves overall scalp environment by reducing sebum, scaling, and microbial overgrowth, thus promoting a more favorable environment for follicular health.
Latanoprost:
Latanoprost binds to the prostaglandin F2α receptor on hair follicle dermal papilla cells, influencing the hair growth cycle as follows:
Increases the duration of anagen, resulting in longer and thicker hair shafts.
May enhance pigmentation in vellus hairs, making them appear darker and more terminal-like.
Some studies suggest latanoprost may increase the number of follicles actively producing hair, particularly in the eyelash and eyebrow regions, and potentially the scalp.
Finasteride
Finasteride is an analog of testosterone that acts as a competitive, specific inhibitor of type II 5-alpha-reductase, an intracellular enzyme that converts testosterone to the potent androgen 5-alpha-dihydrotestosterone. The type II 5-alpha-reductase isozyme is primarily found in prostate, seminal vesicles, epididymides, and hair follicles, as well as liver. Dihydrotestosterone has been shown to increase prostate growth and can lead to hair thinning. Finasteride has been shown to shrink the prostate to improve urinary flow and in the scalp lowers dihydrotestosterone to slow hair loss and promote regrowth.
Adverse Reactions1-7,10-17
Minoxidil
Common
Topical minoxidil is generally well tolerated but may cause local effects:
Local side effects (most common):
Ketoconazole
Common
Latanoprost
Common
Finasteride
Adverse Reactions (with systematic absorption)
Contraindications & Precautions1-7,10-17
Minoxidil
Contraindications:
Precautions:
Ketoconazole
Contraindications:
Precautions:
Latanoprost
Contraindications:
Precautions:
Finasteride
Contraindications & Precautions
Contraindications:
Precautions:
Store in a cool, dry place, away from direct light and heat; Room temperature (20°C–25°C / 68°F–77°F) is ideal.
WPPL operates as a 503A compounding pharmacy and prepares individualized prescription medications pursuant to provider direction. Compounded preparations are not reviewed, tested, or approved by the FDA.
This listing also includes commercially manufactured products for convenience; these items are not compounded by our pharmacy and are sold as provided by their manufacturers. Actual products in stock at time of dispensing may vary due to supply chain variability. Any statements regarding non-compounded products are manufacturer-supplied, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. WPPL does not verify or endorse any therapeutic claims made by manufacturers. Please refer to original labeling for complete product information.
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If you are a physician, clinic, or practice seeking a dependable Compounding Pharmacy partner, WP Pharma Labs is here to help. With dedicated account setup, streamlined ordering and responsive service, we support your therapeutic goals with specialized compounds designed for your patients.
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