Latanoprost (LatanoSTIM) Hair Serum

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Latanoprost (LatanoSTIM) Hair Serum Description1-5

Latanoprost is a prostaglandin F2α (PGF2α) analog that is primarily indicated for the management of open-angle glaucoma and ocular hypertension. Evidence indicates that the drug is associated with hair growth, particularly in cases of androgenetic alopecia (AGA) and eyelash or eyebrow hypotrichosis. Its association with hair regrowth was initially observed as an adverse effect involving increased eyelash growth in patients treated for glaucoma.

References

  1. Johnstone, M. A. (1997). Hypertrichosis and increased pigmentation of eyelashes and adjacent hair in latanoprost therapy. American Journal of Ophthalmology, 120(7), 999–1001.
  2. Blume-Peytavi, U., et al. (2012). Latanoprost stimulates human scalp hair growth in vivo. Journal of the American Academy of Dermatology, 66(5), 807–814.
  3. Kwon, O. S., et al. (2007). Prostaglandin analogs as a potential treatment for hair loss: Latanoprost and bimatoprost in the management of alopecia. International Journal of Dermatology, 46(9), 1044–1048.
  4. Clinical Pharmacology. Elsevier. Latanoprost Monograph. Accessed 2025
  5. FDA Drug Label: Xalatan (latanoprost ophthalmic solution) https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a98595b3-9f47- 48e0-b18d-550a2095f264&type=display Revised May 2023. Accessed June 15, 2025

Mechanism of Action1-5

Latanoprost binds to the prostaglandin F2α receptor on hair follicle dermal papilla cells, influencing the hair growth cycle as follows:

  1. Prolongation of Anagen Phase (Growth Phase):

Increases the duration of anagen, resulting in longer and thicker hair shafts.

  1. Stimulation of Melanogenesis:

May enhance pigmentation in vellus hairs, making them appear darker and more terminal-like.

  1. Increased Follicular Density:

Some studies suggest latanoprost may increase the number of follicles actively producing hair, particularly in the eyelash and eyebrow regions, and potentially the scalp.

Common1-5

  • Local irritation (itching, burning, erythema)
  • Hyperpigmentation of skin (especially around eyelids or eyebrows)
  • Increased pigmentation of treated hair
  • Eyelid darkening (rare with scalp use)
  • Unwanted hair growth if medication spreads to unintended areas
  • Eye irritation (if it migrates to eye area)

Contraindications & Precautions1-5

Contraindications:

  • Known hypersensitivity to latanoprost or prostaglandin analogs
  • Active ocular conditions if near eyes (without ophthalmologic approval)
  • History of herpetic keratitis (due to prostaglandin-induced reactivation risk)

Precautions:

  • Avoid application near the eyes unless specifically prescribed
  • Use gloves or applicator to prevent unintended hair growth on fingers/hands
  • Avoid contact with mucous membranes
  • Patients with a history of uveitis, macular edema, or intraocular surgery should be monitored if periorbital application is required

Store refrigerated (2°C–8°C or 36°F–46°F); protect from light and heat.

  1. Johnstone, M. A. (1997). Hypertrichosis and increased pigmentation of eyelashes and adjacent hair in latanoprost therapy. American Journal of Ophthalmology, 120(7), 999–1001.
  2. Blume-Peytavi, U., et al. (2012). Latanoprost stimulates human scalp hair growth in vivo. Journal of the American Academy of Dermatology, 66(5), 807–814.
  3. Kwon, O. S., et al. (2007). Prostaglandin analogs as a potential treatment for hair loss: Latanoprost and bimatoprost in the management of alopecia. International Journal of Dermatology, 46(9), 1044–1048.
  4. Clinical Pharmacology. Elsevier. Latanoprost Monograph. Accessed 2025
  5. FDA Drug Label: Xalatan (latanoprost ophthalmic solution) https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a98595b3-9f47- 48e0-b18d-550a2095f264&type=display Revised May 2023. Accessed June 15, 2025
This information is for educational purposes only.
This compounded product has not been reviewed, approved, or evaluated by the Food and Drug Administration for safety and effectiveness. This product is not intended to diagnose, treat, cure, or prevent any disease. No claims are made regarding treatment, cure, or prevention of any disease or condition.
This information is a summary. It may not cover all possible drug information about this product. For complete product information, refer to the manufacturer’s prescribing information and labeling. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A WP Pharma Labs pharmacist will be happy to answer any questions. For consultation, please call 1-800-441-0048.

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