Cream
10% / 2%
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Product Overview
Hydroquinone / Kojic Acid Description1,2
Hydroquinone / Kojic Acid is a combined depigmentation or skin-lightening formulation used to manage melasma, chloasma, solar lentigines, freckles, and post-inflammatory hyperpigmentation. This combination is commonly used for hyperpigmentation, as both ingredients inhibit tyrosinase, the key enzyme in melanin synthesis.
Hydroquinone3,4
Hydroquinone is a phenolic organic compound with the molecular formula C₆H₆O₂. It has applications in both the photography and cosmetic industries. There is substantial evidence supporting its use as a skin-lightening agent. Hydroquinone is typically compounded at concentrations ranging from 2% to 12%. Its efficacy and safety depend on the final concentration, the formulation vehicle, and the chemical stability of the product. Skin-lightening effects may become noticeable within approximately two months of use.
Kojic Acid5-7
Kojic acid is an organic acid produced by various fungi, including Aspergillus flavus, A. oryzae, A. tamarii, and A. parasiticus. It was first isolated in 1907 and commercially marketed in 1955. Kojic acid is commonly used as a depigmenting agent and is also associated with antioxidant, antibacterial, and anti-inflammatory properties in addition to its skin-lightening effects.
References
Hydroquinone1-4
Hydroquinone affects the melanogenesis process by inhibiting tyrosinase. It also inhibits DNA and RNA synthesis and suppresses the formation of melanosomes. The ability of hydroquinone to affect the melanocyte metabolic process may lead to a decrease in the production of melanin.
Kojic acid1,2,5-7
Kojic acid is thought to chelate copper. Copper is needed at the active site of the tyrosinase enzyme. This action inhibits the activity of the tyrosinase enzyme. The tyrosinase enzyme is needed for melanin production.
Common3-9
Serious3-9
Contraindications3-9
Precautions3-9
Store at 20–25°C (68–77°F) in a cool, dry place, protected from light and moisture. Keep container tightly closed.
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