GHK-Cu

Facial Cream

0.5% |  2.55%

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Disclaimer: Images are for reference only; actual products may vary.

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Product Overview

GHK-Cu Facial Cream Description1

GHK-Cu is a naturally occurring copper-binding peptide involved in processes related to tissue remodeling and repair. It consists of a tripeptide, glycine, histidine, and lysine, complexed with copper (II). GHK-Cu is found endogenously in human plasma, and its concentration decreases with age.

Topical GHK-Cu formulations are used for their potential to support skin regenerative processes, enhance skin appearance, and promote scalp health. Available evidence also suggests that this peptide may play a role in influencing hair follicle growth.

References

  1. Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. 2018;19(7):1987. doi:10.3390/ijms19071987 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073405/

Mechanism of Action1

The activity of GHK-Cu is thought to be multifaceted and includes:

  1. Gene Modulation:

GHK-Cu has been associated with the upregulation of genes involved in tissue repair, anti-inflammatory signaling, and antioxidant defense, and the downregulation of genes linked to fibrosis and oxidative stress.

  1. Skin Health Support:

Evidence suggests GHK-Cu may enhance dermal fibroblast function, collagen synthesis, and extracellular matrix remodeling—factors that contribute to skin firmness, elasticity, and texture.

  1. Hair Follicle Environment:

GHK-Cu may modulate the follicular microenvironment through support of cell proliferation and anti-inflammatory effects. Preclinical studies have proposed its influence on hair follicle cycling and dermal papilla cell activity.

Common1

  • Mild local irritation
  • Sensitivity to other ingredients when combined in multi-agent products
  • Discoloration or staining

Contraindications1

  • Hypersensitivity to GHK, copper peptides, or excipients
  • Active local infection, open wounds, or compromised skin barrier at site of application

Precautions1

  • Not studied in pregnancy or lactation
  • Avoid contact with mucous membranes and eyes
  • Inform patients of investigational status and variable efficacy
  • Long-term safety and pharmacokinetics in humans are not fully established
  • Store at 2°C–8°C (36°F–46°F)
  • Protect from light, heat, and moisture
  1. Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. 2018;19(7):1987. doi:10.3390/ijms19071987 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073405/
This information is for educational purposes only.
This compounded product has not been reviewed, approved, or evaluated by the Food and Drug Administration for safety and effectiveness. This product is not intended to diagnose, treat, cure, or prevent any disease. No claims are made regarding treatment, cure, or prevention of any disease or condition.
This information is a summary. It may not cover all possible drug information about this product. For complete product information, refer to the manufacturer’s prescribing information and labeling. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A WP Pharma Labs pharmacist will be happy to answer any questions. For consultation, please call 1-800-441-0048.

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