Valproic Acid

Topical Spray

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Disclaimer: Images are for reference only; actual products may vary.

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Product Overview

Product Description

Valproic Acid Description^1-4  

Valproic acid is an antiepileptic medication used in the treatment of partial and absence seizures. While it is most commonly prescribed for seizure disorders, data suggest that valproic acid may support hair growth in individuals with androgenetic alopecia. The effects of topical valproic acid on hair growth have been demonstrated in in vitro culture studies, animal models involving mice, and in a randomized controlled trial conducted in men with androgenetic alopecia. In that randomized controlled trial, valproic acid was associated with an increase in hair count in men with androgenetic alopecia.

References

Clinical Pharmacology valproic acid clinical monograph 2025 https://www.clinicalkey.com/pharmacology/
Choi SY, Kim HD, Kim BJ, Kim MN, Han DH. A case of androgenetic alopecia treated with valproic acid. Int J Dermatol. 2014 Mar;53(3):e214-5.
Jo SJ, Choi SJ, Yoon SY, Lee JY, Park WS, Park PJ, Kim KH, Eun HC, Kwon O. Valproic acid promotes human hair growth in in vitro culture model. J Dermatol Sci. 2013 Oct;72(1):16-24.
Jo SJ, Shin H, Park YW, Paik SH, Park WS, Jeong YS, Shin HJ, Kwon O. Topical valproic acid increases the hair count in male patients with androgenetic alopecia: a randomized, comparative, clinical feasibility study using phototrichogram analysis. J Dermatol. 2014 Apr;41(4):285-91.

Product Mechanism of Action

Mechanism of Action^1-4

The mechanism of how valproic acid stimulates hair growth is related to intracellular pathways and targets. Coordination of signaling between cells is important for formation and maintenance of the hair follicle. β-Catenin is critical for the development and growth of hair follicles through Wnt signaling. Without Wnt signals, β-catenin is phosphorylated by glycogen synthase kinase (GSK)-3 and then degraded. Inhibiting GSK-3 may enhance hair growth. Valproic acid may inhibit GSK-3 to facilitate hair growth.

Product Adverse Reactions

Common ⁴  

Mild itching, erythema

Product Contraindications & Precautions

Contraindications^1-4 

Hypersensitivity or intolerance to valproic acid or excipients
Active local infection, open wounds, or compromised skin barrier at site of application
In patients with known urea cycle disorder (UCD), such as ornithine transcarbamoylase deficiency
Not recommended during pregnancy

Precautions^1-4 

Avoid contact with mucous membranes and eyes

Product Storage

Store at 2°C–8°C (36°F–46°F). Protect from light, heat, and moisture.

Product References

Clinical Pharmacology valproic acid clinical monograph 2025 https://www.clinicalkey.com/pharmacology/
Choi SY, Kim HD, Kim BJ, Kim MN, Han DH. A case of androgenetic alopecia treated with valproic acid. Int J Dermatol. 2014 Mar;53(3):e214-5.
Jo SJ, Choi SJ, Yoon SY, Lee JY, Park WS, Park PJ, Kim KH, Eun HC, Kwon O. Valproic acid promotes human hair growth in in vitro culture model. J Dermatol Sci. 2013 Oct;72(1):16-24.
Jo SJ, Shin H, Park YW, Paik SH, Park WS, Jeong YS, Shin HJ, Kwon O. Topical valproic acid increases the hair count in male patients with androgenetic alopecia: a randomized, comparative, clinical feasibility study using phototrichogram analysis. J Dermatol. 2014 Apr;41(4):285-91.

Product Disclaimer

This information is for educational purposes only.

This compounded product has not been reviewed, approved, or evaluated by the Food and Drug Administration for safety and effectiveness. This product is not intended to diagnose, treat, cure, or prevent any disease. No claims are made regarding treatment, cure, or prevention of any disease or condition.

This information is a summary. It may not cover all possible drug information about this product. For complete product information, refer to the manufacturer’s prescribing information and labeling. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A WP Pharma Labs pharmacist will be happy to answer any questions. For consultation, please call 1-800-441-0048.

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