Bremelanotide (PT-141)

Nasal Spray

10 mg/mL

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Product Overview

Bremelanotide (PT-141) Description1-2

Bremelanotide is a melanocortin receptor (MCR) agonist. It is indicated for the treatment of premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD), defined by low sexual desire that results in significant distress or interpersonal difficulty and is not attributable to:

  • A coexisting medical or psychiatric condition
  • Relationship-related issues, or the effects of medications or other substances

References

  1. Bremelanotide package insert. Revised June 2019. Accessed June 3, 2025. www.accessdata.fda.gov/drugsatfda_docs/label/2019/210557s000lbl.pdf
  2. Clinical Pharmacology bremelanotide clinical monograph 2025 https://www.clinicalkey.com/pharmacology/

Mechanism of Action1-2

Bremelanotide, a MCR agonist, non-selectively works on several receptor subtypes MC1R-MC5R in the central nervous system. MC1R and MC4R are thought to be the most relevant. MC4R are commonly present in the central nervous system. Although the mechanism of action is not fully elucidated, the drug is thought to activate pathways in the brain that are involved in sexual responses.

Adverse Reactions1-2

  • Gastrointestinal including nausea and vomiting
  • Increased blood pressure
  • Hyperpigmentation

Contraindications1-2

  • Known hypersensitivity to bremelanotide or any component of the formulation.
  • Patients with uncontrolled hypertension and cardiovascular disease.
  • Pregnancy not recommended when taking bremelanotide.

Precautions1-2

  • Use caution in patients with renal or hepatic impairment.

Store at or below 25°C (77°F). Do not freeze. Protect from light.

  1. Bremelanotide package insert. Revised June 2019. Accessed June 3, 2025. www.accessdata.fda.gov/drugsatfda_docs/label/2019/210557s000lbl.pdf
  2. Clinical Pharmacology bremelanotide clinical monograph 2025 https://www.clinicalkey.com/pharmacology/
This information is for educational purposes only.
This compounded product has not been reviewed, approved, or evaluated by the Food and Drug Administration for safety and effectiveness. This product is not intended to diagnose, treat, cure, or prevent any disease. No claims are made regarding treatment, cure, or prevention of any disease or condition.
This information is a summary. It may not cover all possible drug information about this product. For complete product information, refer to the manufacturer’s prescribing information and labeling. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A WP Pharma Labs pharmacist will be happy to answer any questions. For consultation, please call 1-800-441-0048.

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