Gonadorelin / Anastrozole, SL

Rapid Dissolve Mini-Tab

300 mcg / 0.25 mg

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Product Overview

Gonadorelin Description1-5

Gonadorelin is a synthetic decapeptide that mirrors the amino acid sequence of naturally occurring gonadotropin-releasing hormone (GnRH). Both substances consist of 10 amino acids arranged in the sequence: pyro-Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂.

In males, FSH and LH are involved in supporting testosterone production and sperm development. In females, these hormones play a role in managing the menstrual cycle and ovulation. The half-life of gonadorelin ranges from approximately 2 to 40 minutes.

Anastrozole Description6-8

Anastrozole is a selective, non-steroidal aromatase inhibitor. It is absorbed quickly, typically within about 2 hours. Its half-life is around 50 hours, and with daily use it generally reaches steady-state levels in about one week. Anastrozole works by reducing estrogen synthesis and influencing testosterone levels.

Gonadorelin1-5

GnRH is made in the hypothalamus and functions to stimulate the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. This increase in FSH and LH may stimulate the production and release of testosterone by the male testes and estrogen by the female ovaries and placenta.

Anastrozole6-8

In postmenopausal women, estrogens are mainly derived from the action of the aromatase enzyme, which converts adrenal androgens (primarily androstenedione and testosterone) to estrone and estradiol. Suppression of estrogen biosynthesis in peripheral tissues and in cancer cells can be achieved by specifically inhibiting the aromatase enzyme. In males, inhibition of the aromatase enzyme results in decreased systemic estrogen levels and increased systemic testosterone levels.

Common Gonadorelin adverse reactions1,2

  • Headache
  • Nausea
  • Abdominal discomfort
  • Flushing
  • Dizziness or lightheadedness
  • Injection site reactions such as redness, pain, or swelling

Common anastrozole adverse reactions6,8

  • Acne
  • Hypertension
  • Gastrointestinal (nausea, vomiting, abdominal pain)
  • Headache
  • Weight gain
  • Osteopenia
  • Insomnia

Contraindications1,2,6,8

  • Intolerance or hypersensitivity to gonadorelin or anastrozole
  • Use in pregnant or breastfeeding women is contraindicated

Precautions1,2,6,8

  • Rare instances of hypersensitivity reaction (bronchospasm, tachycardia, flushing, urticaria, induration at injection site) and anaphylactic reactions have been reported following multiple-dose administration.
  • There has been a report of pituitary apoplexy and sudden blindness following gonadotropin-releasing hormone administration to a patient with a gonadotropin-secreting adenoma.
  • Caution in patients with osteoporosis and coronary artery disease
  • Store at controlled room temperature (20°C to 25°C / 68°F to 77°F)
  • Protect from moisture and light
  • Keep in a tightly closed container
  1. DrugBank. Gonadorelin: Uses, Interactions, Mechanism of Action.
    https://go.drugbank.com/drugs/DB00644 
  2. RxList. Factrel (Gonadorelin): Side Effects, Uses, Dosage https://www.rxlist.com/factrel-drug.htm#description. August 8, 2022
  3. Medicines.org.uk. Gonadorelin 100 mcg Powder for Solution for Injection – SmPC.
    https://www.medicines.org.uk/emc/product/4853/smpc 
  4. DailyMed. GONABREED – Gonadorelin Injection, Solution.
    https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9bc44a48-ff45-468a-a60d-c490a667
  5. Gonadorelin’s Potential Interactions With The Hypothalamic-Pituitary-Gonadal Axis https://www.corepeptides.com/gonadorelins-potential-interactions-with-the-hypothalamic-pituitary-gonadal-axis/ June 7, 2025 Accessed July 14, 2025
  6. Clinical Pharmacology anastrozole clinical monograph 2025 https://www.clinicalkey.com/pharmacology/
  7. De Ronde W, de Jong FH. Aromatase inhibitors in men: effects and therapeutic options. Reprod Biol Endocrinol. 2011 Jun 21;9:93.
  8. Anastrozole (Ascend Laboratories, LLC): FDA Package Insert. https://medlibrary.org/lib/rx/meds/anstrozole-15/. Anastrozole package insert. Revised 03/11 Accessed May 20, 2025

WPPL operates as a 503A compounding pharmacy and prepares individualized prescription medications pursuant to provider direction. Compounded preparations are not reviewed, tested, or approved by the FDA.

This listing also includes commercially manufactured products for convenience; these items are not compounded by our pharmacy and are sold as provided by their manufacturers. Any statements regarding non-compounded products are manufacturer-supplied, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. WPPL does not verify or endorse any therapeutic claims made by manufacturers. Please refer to original labeling for complete product information.

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