(Ship Cold) Nasal Spray
0.2 mg per 0.1 mL Spray
Product Overview
Synapsin® Description1-7
Synapsin® Nasal Spray is a compounded prescription formulation intended to support neurological health and cognitive function. It is administered intranasally to bypass the blood–brain barrier and facilitate delivery of the medication to the brain. The formulation contains ginsenoside Rg3 and nicotinamide riboside as its active components.
Ginsenoside Rg31,2
The ginseng plant contains more than 100 different ginsenosides. Ginsenoside Rg3, one of the most extensively studied ginsenosides derived from Panax ginseng, may exhibit notable pharmacological activity, including hepatoprotective, neuroprotective, and immune-supporting properties. It may also demonstrate antioxidant, anti-inflammatory, and anti-tumor effects. The primary ginsenosides—Rb1, Rb2, and Rd—can be readily metabolized into ginsenoside Rg3.
Nicotinamide Riboside3,4
Nicotinamide riboside is a form of vitamin B3 and functions as a precursor to NAD⁺, similar to nicotinamide and nicotinic acid. It serves as a potent NAD⁺ enhancer. Nicotinamide riboside may support conditions related to neurodegeneration, metabolic dysfunction, and cardiac fibrosis. In particular, it may influence inflammatory processes associated with Alzheimer’s disease and other neurodegenerative disorders. In individuals with Alzheimer’s disease, NAD⁺ levels are often reduced, which may be associated with neuroinflammation, cellular injury, and increased proinflammatory cytokines.
Ginsenoside Rg31,2
Ginsenoside’s actions to decrease inflammation in neurogenerative diseases is related to its effect on signaling pathways such as activator protein 1 and protein kinase A and the regulation of inflammatory mediators such as cytokines and nitric oxide. Ginsenosides may improve learning and memory through their effect on signaling pathways and mediators. It is thought that ginsenoside may reduce neuroinflammation and promote survival.
Nicotinamide Riboside3,4
Nicotinamide riboside increases intracellular NAD+ levels. NAD+ is critical for metabolism and physiological function. It accepts electrons during metabolic reactions to become NADH (reduced form). NADH uses the electron to donate to other molecules. This is important for ATP production in the body. This process occurs during glycolysis, fatty acid oxidation, and the TCA cycle. There is a continuous conversion of NAD+ to NADH in cells in the body which is critical for energy flow. NAD+ is also important for sirtuin regulation (DNA repair, inflammation processes, and fat metabolism). It is a substrate for PARPs (poly (ADP-ribose) polymerases) (repair of damaged DNA), and is important to prevent neurodegenerative processes.
Common5-7
Nasal irritation, stinging sensation upon administration, headache, flushing, insomnia
Contraindications5-7
Known intolerance or hypersensitivity to Ginsenoside Rg3 or Nicotinamide Riboside
Precautions5-7
Store Synapsin® Nasal Spray in the refrigerator at 2°C to 8°C (36°F to 46°F). Protect from light and keep the bottle upright. Before using allow the spray to reach room temperature to minimize nasal discomfort .
WPPL operates as a 503A compounding pharmacy and prepares individualized prescription medications pursuant to provider direction. Compounded preparations are not reviewed, tested, or approved by the FDA.
This listing also includes commercially manufactured products for convenience; these items are not compounded by our pharmacy and are sold as provided by their manufacturers. Actual products in stock at time of dispensing may vary due to supply chain variability. Any statements regarding non-compounded products are manufacturer-supplied, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. WPPL does not verify or endorse any therapeutic claims made by manufacturers. Please refer to original labeling for complete product information.
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