(Ship Cold) Nasal Spray
50 mcg per 0.1 mL Spray
Product Overview
Vasoactive Intestinal Peptide (VIP) Description1-6
Vasoactive intestinal polypeptide (VIP) is a peptide composed of 28 amino acids. It functions as a neuropeptide and serves as a neurotransmitter within both the central and peripheral nervous systems. VIP exhibits vasodilatory activity, affects smooth muscle function, particularly within the respiratory and gastrointestinal tracts, and plays a role in regulating gastrointestinal blood flow. This formulation is compounded as a nasal spray to facilitate delivery to the central nervous system and absorption into systemic circulation. Clinically, VIP has been used in the management of chronic inflammatory response syndrome, respiratory conditions such as asthma, chronic obstructive pulmonary disease, cystic fibrosis, pulmonary hypertension, and sarcoidosis.
Mechanism of Action1-6
Vasoactive intestinal polypeptide (VIP) is found in the peripheral, gastrointestinal and central nervous systems. It is produced by immunomodulatory T cells. Studies have shown that VIP is in nerve fibers in the following organ and systems: gastrointestinal tract, respiratory airways, pancreas, sensory organs, and reproductive system. It binds to two receptors VPAC1 and VPAC2. VIP receptors are found in various tissues in the gastrointestinal tract and brain. Receptors are specifically found on smooth muscle of sphincters of the lower esophagus, ampulla of Vater, and rectum. VIP regulates sphincter relaxation. VIP receptors on pancreatic acinar and duct cells and enteric mucosal cells mediate fluid secretion in these organs. In the lungs, VPAC1 is found in the lung tissue and VPAC2 is essentially found in the lung smooth muscles.
VIP activates adenylate cyclase and increases cyclic AMP (cAMP) levels. This activity of VIP may have the following activities: anti-inflammatory (immune modulation), vasodilation (enhances blood flow and reduces vascular resistance especially respiratory tract), neuroprotection, and regulation of smooth muscle to help with motility and digestive health.
Common1-6
Flushing, warmth sensation, nasal irritation, dizziness, nausea and vomiting and headache.
Contraindications1-6
Precautions1-6
Store VIP nasal spray in a refrigerator at 2°C to 8°C (36°F to 46°F). Do not freeze. Protect from light and keep the bottle upright. Discard any unused portion after the expiration date indicated on the label.
WPPL operates as a 503A compounding pharmacy and prepares individualized prescription medications pursuant to provider direction. Compounded preparations are not reviewed, tested, or approved by the FDA.
This listing also includes commercially manufactured products for convenience; these items are not compounded by our pharmacy and are sold as provided by their manufacturers. Actual products in stock at time of dispensing may vary due to supply chain variability. Any statements regarding non-compounded products are manufacturer-supplied, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. WPPL does not verify or endorse any therapeutic claims made by manufacturers. Please refer to original labeling for complete product information.
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