Tirzepatide Zepbound®

(Commercial Product) Prefilled Pen Solution for Injection

2.5 mg / 0.5 mL  |  5 mg / 0.5 mL  |  7.5 mg / 0.5 mL  |  10 mg / 0.5 mL  |  12.5 mg / 0.5 mL  |  15 mg / 0.5 mL

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Product Overview

Tirzepatide Description 1-4

Tirzepatide is a novel dual agonist of the glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors. It is administered as a once-weekly subcutaneous injection and is indicated for use alongside a reduced-calorie diet and increased physical activity to support reduction of excess body weight and the long-term maintenance of weight reduction in adults with obesity or who are overweight.

Mechanism of Action1-3 

Tirzepatide exerts its effects through dual incretin receptor agonism, targeting both:

  1. GIP (Glucose-dependent Insulinotropic Polypeptide) Receptor:
  • Enhances insulin secretion
  • Reduces glucagon secretion
  • Promotes lipid metabolism and may contribute to weight loss
  1. GLP-1 (Glucagon-Like Peptide-1) Receptor:
  • Delays gastric emptying
  • Reduces appetite
  • Stimulates insulin release in a glucose-dependent manner
  • Inhibits glucagon release during hyperglycemia

Adverse Reactions1-4

Most adverse reactions are gastrointestinal in nature and dose-dependent:

  • Gastrointestinal: Nausea, vomiting, diarrhea, constipation, dyspepsia, decreased appetite, abdominal pain
  • Headache, dizziness, and injection site reactions

Contraindications & Precautions1-4

Contraindications:

  • Personal or family history of medullary thyroid carcinoma (MTC)
  • Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
  • History of serious hypersensitivity to tirzepatide or any component of the formulation
  • Nonketotic hyperglycinemia (NKH) or other genetic disorders preventing absorption of amino acids.

Precautions:

  • Pancreatitis risk: Monitor patients for signs/symptoms (serious abdominal pain)
  • Severe gastrointestinal disease: Use with caution; only if benefit outweighs potential risk.
  • Acute kidney injury: Especially in those with dehydration, vomiting, or diarrhea.
  • Diabetic retinopathy: Rapid improvement in glucose may worsen retinopathy.
  • Use with insulin or secretagogues: Dose adjustment may be necessary to reduce hypoglycemia risk.
  • Pregnancy & Lactation: No adequate data; not recommended. Use only if benefit outweighs potential risk. Discontinue at least 1 month prior to a planned pregnancy due to long half-life

Store refrigerated at 36°F to 46°F (2°C – 8°C). Discard within 28 days of puncture or according to the beyond-use date. Do not freeze. Keep out of reach of children.

  1. Clinical Pharmacology powered by Elsevier (ClinicalKey) – Tirzepatide Monograph. https://www.clinicalkey.com
Accessed February 5, 2026.
  2. FDA Prescribing Information – Zepbound® (tirzepatide): https://www.accessdata.fda.gov/drugsatfda_docs/label/2024/217806s013lbl.pdf Lilly USA, LLC, Indianapolis, IN 46285, USA March 2023. Accessed February 5, 2026
  3. Jastreboff AM, et al. “Tirzepatide Once Weekly for the Treatment of Obesity.” NEJM. 2022; 387(3):205–216. https://www.nejm.org/doi/full/10.1056/NEJMoa2206038

  4. Drucker DJ. “Mechanisms of Action and Therapeutic Application of GLP-1 and GIP.” Cell Metabolism. 2018. https://doi.org/10.1016/j.cmet.2018.06.015

WPPL operates as a 503A compounding pharmacy and prepares individualized prescription medications pursuant to provider direction. Compounded preparations are not reviewed, tested, or approved by the FDA.

This listing also includes commercially manufactured products for convenience; these items are not compounded by our pharmacy and are sold as provided by their manufacturers. Actual products in stock at time of dispensing may vary due to supply chain variability. Any statements regarding non-compounded products are manufacturer-supplied, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. WPPL does not verify or endorse any therapeutic claims made by manufacturers. Please refer to original labeling for complete product information.

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