Testosterone Cypionate / DHEA

Injection

200 mg / 25 mg / mL

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Product Overview

Testosterone Cypionate / DHEA Description1-7

Testosterone Cypionate / DHEA is a compounded injectable combination of the steroid hormone testosterone and the precursor hormone dehydroepiandrosterone (DHEA).

Testosterone Cypionate / DHEA Injection is used in testosterone replacement therapy to address declining testosterone levels associated with hypogonadism and to support energy, mood, and sexual health.

Testosterone cypionate is a long-acting testosterone ester with an approximate half-life of 8 days. In contrast, non-esterified (free) testosterone has a very short half-life of approximately 10 minutes. Esterification significantly prolongs the duration of action, allowing for sustained testosterone levels.

Dehydroepiandrosterone (DHEA) is an endogenous steroid hormone produced primarily in the adrenal cortex, with smaller amounts synthesized in the gonads and brain. It functions as a precursor to both androgens and estrogens, including testosterone and estradiol. DHEA levels naturally decline with age, and supplementation is commonly used to support age-related hormone decline, adrenal function, mood, and sexual health.

Mechanism of Action1-7

Testosterone Cypionate is an esterified form of testosterone. The ester extends the duration of action and is useful for less frequent, intramuscular, or subcutaneous injections. Once administered, the ester is cleaved, releasing free testosterone into the bloodstream. Testosterone then binds to androgen receptors in various tissues, exerting anabolic and androgenic effects. These effects may include the development and maintenance of male secondary sexual characteristics, stimulation of muscle and bone growth, and regulation of libido and mood. 

Dehydroepiandrosterone (DHEA) is a prohormone, meaning its physiological effects are largely mediated through conversion to active androgens (like testosterone) and estrogens (like estradiol).

Endocrine effects:

  • In peripheral tissues, DHEA is converted to androstenedione, then to testosterone, estrone, and estradiol via tissue-specific enzymes such as 3β-HSD, 17β-HSD, aromatase.

Neurosteroid activity:

  • DHEA may interact with GABA-A and NMDA receptors, contributing to its neuromodulatory, antidepressant, and anxiolytic properties.

Common 1-7

  • Acne
  • Hypertension
  • Gastrointestinal (nausea, vomiting, abdominal pain)
  • Headache
  • Weight gain
  • Insomnia
  • Injection site pain or inflammation
  • Mood swings or irritability
  • Increased or decreased libido
  • Gynecomastia

Contraindications 1-7

  • Known hypersensitivity to testosterone, cypionate or any component of the formulation
  • Known hypersensitivity to DHEA
  • Known hypersensitivity to grapeseed oil
  • Males with carcinoma of the breast or known or suspected carcinoma of the prostate
  • Pregnant or breastfeeding women
  • Patients with serious cardiac, hepatic, or renal disease

Precautions 1-7

  • Monitor hematocrit and hemoglobin levels.
  • Regularly assess liver function tests.
  • Evaluate lipid profiles periodically.
  • Monitor for signs of sleep apnea.
  • Use cautiously in patients with a history of cardiovascular disease.

Store at 20°C to 25°C (68°F to 77°F) in a dry place, away from heat and light. DO NOT REFRIGERATE. Do not freeze. Keep out of reach of children.

WPPL operates as a 503A compounding pharmacy and prepares individualized prescription medications pursuant to provider direction. Compounded preparations are not reviewed, tested, or approved by the FDA.

This listing also includes commercially manufactured products for convenience; these items are not compounded by our pharmacy and are sold as provided by their manufacturers. Actual products in stock at time of dispensing may vary due to supply chain variability. Any statements regarding non-compounded products are manufacturer-supplied, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. WPPL does not verify or endorse any therapeutic claims made by manufacturers. Please refer to original labeling for complete product information.

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