(Ship Cold) Gel Troche
50 U / 100 mg | 125 U / 100 mg
Product Overview
Oxytocin Gel Troche Description1-6
Oxytocin is synthesized in the hypothalamus and stored in the posterior pituitary gland. A synthetic form of oxytocin is available and exhibits the same activity as the naturally occurring hormone. Oxytocin promotes contraction of uterine smooth muscle during labor and stimulates the alveolar ducts of the breast to release milk following its production. Due to its effects on uterine activity, oxytocin has been used to initiate labor, assist with placental delivery, and manage postpartum hemorrhage. Oxytocin has also been linked to social bonding, mood modulation, and sexual function.
Sildenafil Gel Troche Description7,8
Sildenafil, a phosphodiesterase type 5 (PDE5) inhibitor, has a half-life of 4 hours. Clinically, the drug is used to treat erectile dysfunction and pulmonary hypertension. Because of the half-life the drug is used “on-demand” prior to sexual activity.
Oxytocin1-6
Oxytocin causes G-protein coupled receptors to increase intracellular calcium which leads to uterine contraction. The stimulation of uterine contractions causes more oxytocin to be released. As more oxytocin is released it positively influences even more release of oxytocin. This release of oxytocin is called positive feedback which is much different than how many hormones work in the endocrine system. Oxytocin administered exogenously causes the same response as endogenously produced oxytocin. Not only does oxytocin stimulate uterine contractions, but it also causes contractions of myoepithelial cells in the alveolar ducts found in female breast tissue. These contractions force milk from these ducts into even larger sinuses, which subsequently enables milk expulsion. When a baby attempts to latch onto the mother’s breast it causes oxytocin secretion into the blood in the same manner as vaginal delivery; instead of uterine contractions, milk is ejected from the breast. Similar to the actions of oxytocin in the uterus to stimulate contractions during delivery, milk-ejection from breast tissue occurs due to positive feedback. In the brain, it is proposed that oxytocin stimulates social and sexual function by its activity in many areas of the brain including its activity on neurotransmitters.
Sildenafil7-9
Phosphodiesterase (PDE) has many isoforms and is an enzyme that has many functions in the body including degrading the effect of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). PDE5 is an enzyme that is found in many parts of the body including in the smooth muscle of the corpus cavernosum, prostate, bladder, the vascular and visceral smooth muscle, skeletal muscle, urethra, platelets, kidney, lung, cerebellum, heart, liver, testis, seminal vesicle, and pancreas. Sildenafil is structurally similar to cGMP and prevents degradation of cGMP by competitively binding and inhibiting activity of PDE5. When PDE5 is inhibited, cGMP accumulates and leads to smooth muscle relaxation. In the corpus cavernosum, this leads to penile erection. In the pulmonary system, it leads to vasodilation in the pulmonary arteries.
Oxytocin1,3
Common
Sildenafil7,8
Common
Oxytocin1,3
Contraindications
Precautions
Sildenafil7,8
Contraindications:
Precautions:
Store at controlled room temperature 20–25°C (68–77°F) or may be stored in the refrigerator. Keep in a dry place. Protect from light, heat, and moisture. Keep out of reach of children and pets.
WPPL operates as a 503A compounding pharmacy and prepares individualized prescription medications pursuant to provider direction. Compounded preparations are not reviewed, tested, or approved by the FDA.
This listing also includes commercially manufactured products for convenience; these items are not compounded by our pharmacy and are sold as provided by their manufacturers. Actual products in stock at time of dispensing may vary due to supply chain variability. Any statements regarding non-compounded products are manufacturer-supplied, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. WPPL does not verify or endorse any therapeutic claims made by manufacturers. Please refer to original labeling for complete product information.
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