Solution
5% / 0.025% / 0.25% / 0.1%
Product Overview
This formulation combines minoxidil, tretinoin, progesterone, and finasteride to target hormonally related hair loss. Each component works through a distinct mechanism to support hair development and growth. The combined formulation is designed to encourage thicker, stronger hair while supporting ongoing scalp and follicular health.
Minoxidil 1-3
Topical minoxidil is a vasodilator that was initially developed as an oral antihypertensive medication. Its hair growth–stimulating effects were identified following observations of hypertrichosis (excessive or abnormal hair growth) in patients receiving oral minoxidil. It was later approved by the FDA for the treatment of androgenetic alopecia in both men and women.
Tretinoin4-7
Tretinoin, also known as all-trans-retinoic acid, is a naturally occurring derivative of vitamin A. Retinoids are involved in the regulation of cell reproduction, proliferation, and differentiation. When used in combination, tretinoin and minoxidil may produce a synergistic effect by increasing the expression of hair growth–related markers such as Erk, Akt, Bcl-2, and Bax.
Progesterone8-10
Micronized progesterone is a bioidentical form of the naturally occurring hormone progesterone and is used in women’s health applications, including hormone replacement therapy (HRT) and prevention of endometrial hyperplasia in postmenopausal women receiving estrogen therapy. Progesterone may also have a role in supporting or maintaining hair growth.
Finasteride Description11-14
Finasteride is a 5-alpha reductase inhibitor that has demonstrated benefit in individuals with female pattern hair loss. Topical finasteride has been shown to improve hair density and hair growth in both premenopausal and postmenopausal women.
Minoxidil1-3
The drug has many mechanisms in supporting hair growth:
Tretinoin4-7
Tretinoin may have several mechanisms to facilitate hair growth including the following:
Progesterone8-10
Finasteride11-14
Finasteride is an analog of testosterone that acts as a competitive, specific inhibitor of type II 5-alpha-reductase, an intracellular enzyme that converts testosterone to the potent androgen 5-alpha-dihydrotestosterone. The type II 5-alpha-reductase isozyme is found in the scalp hair follicles. Finasteride may decrease dihydrotestosterone levels through its effect on increasing insulin growth factor-1 production in the dermal papillae.
Minoxidil1-3
Common
Topical minoxidil is generally well tolerated but may cause local effects including the following:
Tretinoin4-7
Common
Skin irritation, such as peeling, xerosis (dry skin), burning, stinging, erythema, and pruritus
Progesterone8-10
Common (with systemic absorption) (topical application is not expected to be absorbed significantly systemically)
Finasteride11-14
Common
With systemic absorption (rare)
Contraindications1,2,4,8,11
Precautions1,2,4,8,11
Store at controlled room temperature, between 68°F to 77°F (20°C to 25°C). Protect from light and keep the container tightly closed. Women should not handle crushed or broken finasteride tablets when they are pregnant or may potentially be pregnant because of the possibility of absorption of finasteride and the subsequent potential risk to a male fetus. Keep out of reach of children and pets.
WPPL operates as a 503A compounding pharmacy and prepares individualized prescription medications pursuant to provider direction. Compounded preparations are not reviewed, tested, or approved by the FDA.
This listing also includes commercially manufactured products for convenience; these items are not compounded by our pharmacy and are sold as provided by their manufacturers. Actual products in stock at time of dispensing may vary due to supply chain variability. Any statements regarding non-compounded products are manufacturer-supplied, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. WPPL does not verify or endorse any therapeutic claims made by manufacturers. Please refer to original labeling for complete product information.
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Providers: Let’s Partner for Better Patient Care
If you are a physician, clinic, or practice seeking a dependable Compounding Pharmacy partner, WP Pharma Labs is here to help. With dedicated account setup, streamlined ordering and responsive service, we support your therapeutic goals with specialized compounds designed for your patients.
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