Cream
4% | 8%
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Product Overview
Hydroquinone with Vitamin D is a depigmentation or skin-lightening formulation used to manage melasma, chloasma, solar lentigines, freckles, and post-inflammatory hyperpigmentation.
Hydroquinone3,4
Hydroquinone is a phenolic organic compound with the molecular formula C₆H₆O₂. It has applications in both the photography and cosmetic industries. There is substantial evidence supporting its use as a skin-lightening agent. Hydroquinone is typically compounded at concentrations ranging from 2% to 12%. Its efficacy and safety depend on the final concentration, the formulation vehicle, and the chemical stability of the product. Skin-lightening effects may become noticeable within approximately two months of use.
Vitamin D5-8
Vitamin D is a fat-soluble vitamin first discovered in the early 1920s. It exists in two primary forms: D2 (ergocalciferol) and D3 (cholecalciferol). Vitamin D is essential for supporting bone health, enhancing immune function, and regulating calcium and phosphorus levels. In the body, vitamin D is inactive and must be activated to exert its physiological effects. It can be obtained through sun exposure, dietary sources, or supplements. When applied topically, vitamin D has been shown to be absorbed through the skin, producing systemic levels.
References
Hydroquinone1-4
Hydroquinone affects the melanogenesis process by inhibiting tyrosinase. It also inhibits DNA and RNA synthesis and suppresses the formation of melanosomes. The ability of hydroquinone to affect the melanocyte metabolic process may lead to a decrease in the production of melanin.
Vitamin D5-8
Vitamin D (D2 or D3) is absorbed in the gastrointestinal tract and bound to lipoproteins and stored in fat tissue or muscle. It is activated by going through two hydroxylations. The first hydroxylation changes inert vitamin D to 25-hydroxyvitamin D (calcidiol) and the second hydroxylation changes it to the physiologically active form, 1,25 dihydroxyvitamin D (calcitriol). It is hydroxylated in the liver to form 25-hydroxylated derivatives. It is further hydroxylated to 1,25 cholecalciferol or ergocalciferol (activated form calcitriol) in the kidney. Normal 25-hydroxyvitamin D is generally between 40 and 60 ng/mL. Calcitriol facilitates the reabsorption of calcium from the kidney and reabsorption of calcium and phosphorus from the gastrointestinal tract. It helps to mobilize calcium from the bone. Calcitriol binds to the vitamin D receptor in the nucleus inside the cell. Through this binding to the vitamin D receptor gene transcription is modified with activation of specific genes and suppression of others.
Common3-10
Serious10
Contraindications3-9
Precautions3-9
Store at 20–25°C (68–77°F) in a cool, dry place, protected from light and moisture. Keep container tightly closed.
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