BLT (Benzocaine / Lidocaine / Tetracaine)

Cream for Laser and Non-Laser Use *Patient Specific 503A Orders

20% / 6% / 4%
20% / 10% / 4%

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Product Overview

BLT (Benzocaine / Lidocaine / Tetracaine) Description1-5

Benzocaine / Lidocaine / Tetracaine (BLT) Cream is a compounded topical formulation that combines three anesthetic agents and is used prior to dermatologic procedures such as laser treatments, tattooing, microneedling, and dermal filler injections. Local anesthetics applied to the skin are classified as either amino amides or amino esters. Lidocaine belongs to the amino amide class, while benzocaine and tetracaine are categorized as amino esters.

Benzocaine has an onset of action of approximately one minute, with effects lasting about 15 to 20 minutes. Tetracaine typically begins working within 3 to 10 minutes and has a duration of action of roughly 30 to 60 minutes. Lidocaine has an onset of action of about 1 to 2 minutes and a duration of action of approximately 15 minutes. The combination provides both rapid onset and extended numbing effects by utilizing the distinct pharmacokinetic properties of each component. Benzocaine and tetracaine are both ethyl esters of p-aminobenzoic acid.

References

  1. Garmon EH, Hendrix JM, Huecker MR. Topical, Local, and Regional Anesthesia and Anesthetics. StatPearls February 21, 2025. Accessed August 2, 2025
  2. Lee HS. Recent advances in topical anesthesia. J Dent Anesth Pain Med. 2016 Dec;16(4):237-244.
  3. Clinical Pharmacology benzocaine clinical monograph 2025 https://www.clinicalkey.com/pharmacology/  Clinical Pharmacology
  4. Clinical Pharmacology lidocaine clinical monograph 2025 https://www.clinicalkey.com/pharmacology/
  5. Clinical Pharmacology tetracaine clinical monograph 2025 https://www.clinicalkey.com/pharmacology/

Mechanism of Action1-5

The mechanism of action for these local anesthetics of benzocaine, lidocaine and tetracaine is to reversibly block voltage-gated sodium channels. They prevent sodium from moving into the nerve cells and stop the impulse transmission. These drugs block sodium in a use dependent manner meaning that the higher the firing rate, the more efficacious the drug is in blocking the sodium channel.

Common1-5

  • Localized redness, itching, or transient burning at the application site
  • Temporary numbness or tingling

Contraindications & Precautions

Contraindications1-5

  • Known hypersensitivity to benzocaine, lidocaine, tetracaine, or PABA derivatives
  • Use on broken or inflamed skin increases systemic absorption and risk of toxicity

Precautions1-5

  • Avoid occlusive dressings over application sites to reduce systemic absorption
  • Monitor pediatric patients and the elderly more closely due to increased sensitivity

Store at 20–25°C (68–77°F) in a dry place, protected from light and heat [8]. Do not freeze. Keep out of reach of children.

  1. Garmon EH, Hendrix JM, Huecker MR. Topical, Local, and Regional Anesthesia and Anesthetics. StatPearls February 21, 2025. Accessed August 2, 2025
  2. Lee HS. Recent advances in topical anesthesia. J Dent Anesth Pain Med. 2016 Dec;16(4):237-244.
  3. Clinical Pharmacology benzocaine clinical monograph 2025 https://www.clinicalkey.com/pharmacology/  Clinical Pharmacology
  4. Clinical Pharmacology lidocaine clinical monograph 2025 https://www.clinicalkey.com/pharmacology/
  5. Clinical Pharmacology tetracaine clinical monograph 2025 https://www.clinicalkey.com/pharmacology/
This information is for educational purposes only.
This compounded product has not been reviewed, approved, or evaluated by the Food and Drug Administration for safety and effectiveness. This product is not intended to diagnose, treat, cure, or prevent any disease. No claims are made regarding treatment, cure, or prevention of any disease or condition.
This information is a summary. It may not cover all possible drug information about this product. For complete product information, refer to the manufacturer’s prescribing information and labeling. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A WP Pharma Labs pharmacist will be happy to answer any questions. For consultation, please call 1-800-441-0048.

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