Capsule
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Product Overview
DHEA SR in K100M Description1-3
Dehydroepiandrosterone (DHEA) is an endogenous steroid hormone produced mainly by the adrenal cortex, with smaller amounts synthesized in the gonads and the brain. It acts as a precursor to both androgens and estrogens, including testosterone and estradiol. DHEA levels naturally decrease with age, and supplementation is used in contexts such as age-related hormonal decline, adrenal insufficiency, mood support, and sexual health.
Transdermal DHEA may be compounded into a cream or gel for application to the skin, enabling systemic absorption while bypassing first-pass hepatic metabolism. This route of administration may help minimize side effects and support more consistent hormone levels compared with oral DHEA.
Mechanism of Action1-3
DHEA is a prohormone, meaning its physiological effects are largely mediated through conversion to active androgens (like testosterone) and estrogens (like estradiol).
Endocrine effects:
In peripheral tissues, DHEA is converted to androstenedione, then to testosterone, estrone, and estradiol via tissue-specific enzymes such as 3β-HSD, 17β-HSD, aromatase.
Neurosteroid activity:
DHEA may interact with GABA-A and NMDA receptors, contributing to its neuromodulatory, antidepressant, and anxiolytic properties.
Contraindications1-3
Precautions1-3
Mild to moderate1-3
Less common but notable1-3
WPPL operates as a 503A compounding pharmacy and prepares individualized prescription medications pursuant to provider direction. Compounded preparations are not reviewed, tested, or approved by the FDA.
This listing also includes commercially manufactured products for convenience; these items are not compounded by our pharmacy and are sold as provided by their manufacturers. Actual products in stock at time of dispensing may vary due to supply chain variability. Any statements regarding non-compounded products are manufacturer-supplied, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. WPPL does not verify or endorse any therapeutic claims made by manufacturers. Please refer to original labeling for complete product information.
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If you are a physician, clinic, or practice seeking a dependable Compounding Pharmacy partner, WP Pharma Labs is here to help. With dedicated account setup, streamlined ordering and responsive service, we support your therapeutic goals with specialized compounds designed for your patients.
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