Capsule
45 mg / 20 mg
Product Overview
Clomiphene (Clomid™) Description1,2,3
Clomiphene, originally marketed as Clomid™, is a fertility medication used to induce ovulation in women who ovulate infrequently or not at all. It stimulates ovulation in patients with an intact hypothalamic-pituitary-ovarian axis and normally functioning ovaries. In women, clomiphene promotes the release of pituitary gonadotropins, initiating steroidogenesis and folliculogenesis, which leads to ovarian follicle development and increased circulating estradiol levels. In men with low testosterone, the drug can increase testosterone levels through stimulation of LH and FSH production.
Pregnenolone Description4-6
Pregnenolone is a naturally occurring endogenous steroid and a precursor in the biosynthesis of various other steroids, including progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens. It is primarily synthesized in the adrenal glands, with smaller amounts produced in the liver, gonads, brain, and skin.
Pregnenolone is a compounded preparation designed for systemic absorption through the skin, typically formulated in a lipophilic cream or gel base or taken by mouth in capsule form. It is used for supporting cognitive function, managing adrenal fatigue, improving mood, and alleviating symptoms associated with hormonal imbalances, such as those in perimenopause and andropause.
Clomiphene Mechanism of Action1-3
Clomiphene is classified as a selective-estrogen receptor-modulator due to its ability to compete with estradiol for estrogen receptors at the level of the hypothalamus. The drug blocks the normal negative feedback of circulating estradiol on the hypothalamus, preventing estrogen from lowering the output of gonadotropin releasing hormone. Gonadotropin releasing hormone pulses increases during clomiphene therapy and stimulates the pituitary gland to release more FSH and LH. For women, FSH and LH stimulate the ovaries to develop oocyte follicles. For men, it stimulates the production of testosterone.
Pregnenolone Mechanism of Action4-6
Pregnenolone functions as a neurosteroid and hormonal precursor. After absorption, it enters systemic circulation and is converted into downstream hormones depending on enzymatic activity in target tissues.
Neurosteroid effects: It modulates GABA-A receptors indirectly and can enhance cognitive performance and reduce anxiety in some settings.
Endocrine pathway: Pregnenolone is the parent molecule in the steroidogenic pathway. It undergoes enzymatic conversion to:
– Progesterone via 3β-HSD
– DHEA via 17α-hydroxylation followed by cleavage
– And further into testosterone, estradiol, cortisol, and aldosterone depending on tissue-specific enzymes
Clomiphene Adverse Reactions1,2
Pregnenolone Adverse Effects4-6
Common
Less common but possible
Clomiphene Contraindications & Precautions1,2
Contraindications
Precautions
Pregnenolone Contraindications / Precautions4-6
Contraindications
Precautions
WPPL operates as a 503A compounding pharmacy and prepares individualized prescription medications pursuant to provider direction. Compounded preparations are not reviewed, tested, or approved by the FDA.
This listing also includes commercially manufactured products for convenience; these items are not compounded by our pharmacy and are sold as provided by their manufacturers. Actual products in stock at time of dispensing may vary due to supply chain variability. Any statements regarding non-compounded products are manufacturer-supplied, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. WPPL does not verify or endorse any therapeutic claims made by manufacturers. Please refer to original labeling for complete product information.
EXPLORE MORE
Related Medications
Licensed to ship across the U.S.
Your orders arrive promptly and privately, delivered directly to your door.
Providers: Let’s Partner for Better Patient Care
If you are a physician, clinic, or practice seeking a dependable Compounding Pharmacy partner, WP Pharma Labs is here to help. With dedicated account setup, streamlined ordering and responsive service, we support your therapeutic goals with specialized compounds designed for your patients.
To check product availability, check on the status of an existing order, request refills:
orders@wppharmalabs.com
New providers setup / update an existing account:
newaccounts@wppharmalabs.com
