Bremelanotide (PT-141)

Nasal Spray

10 mg/mL

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Product Overview

Bremelanotide (PT-141) Description1-2

Bremelanotide is a melanocortin receptor (MCR) agonist. It is indicated for the treatment of premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD), defined by low sexual desire that results in significant distress or interpersonal difficulty and is not attributable to:

  • A coexisting medical or psychiatric condition
  • Relationship-related issues, or the effects of medications or other substances

Mechanism of Action1-2

Bremelanotide, a MCR agonist, non-selectively works on several receptor subtypes MC1R-MC5R in the central nervous system. MC1R and MC4R are thought to be the most relevant. MC4R are commonly present in the central nervous system. Although the mechanism of action is not fully elucidated, the drug is thought to activate pathways in the brain that are involved in sexual responses.

Adverse Reactions1-2

  • Gastrointestinal including nausea and vomiting
  • Increased blood pressure
  • Hyperpigmentation

Contraindications1-2

  • Known hypersensitivity to bremelanotide or any component of the formulation.
  • Patients with uncontrolled hypertension and cardiovascular disease.
  • Pregnancy not recommended when taking bremelanotide.

Precautions1-2

  • Use caution in patients with renal or hepatic impairment.

Store at or below 25°C (77°F). Do not freeze. Protect from light.

  1. Bremelanotide package insert. Revised June 2019. Accessed June 3, 2025. www.accessdata.fda.gov/drugsatfda_docs/label/2019/210557s000lbl.pdf
  2. Clinical Pharmacology bremelanotide clinical monograph 2025 https://www.clinicalkey.com/pharmacology/

WPPL operates as a 503A compounding pharmacy and prepares individualized prescription medications pursuant to provider direction. Compounded preparations are not reviewed, tested, or approved by the FDA.

This listing also includes commercially manufactured products for convenience; these items are not compounded by our pharmacy and are sold as provided by their manufacturers. Actual products in stock at time of dispensing may vary due to supply chain variability. Any statements regarding non-compounded products are manufacturer-supplied, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. WPPL does not verify or endorse any therapeutic claims made by manufacturers. Please refer to original labeling for complete product information.

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