Aminophylline / Arginine

Gel

3% / 6%

Ready to prescribe?

Disclaimer: Images are for reference only; actual products may vary.

Product Overview

Product Description

Aminophylline / Arginine Description^1-5

Compounded Aminophylline / Arginine Gel is a topical formulation intended to support female sexual arousal and genital sensitivity. It contains two active ingredients: aminophylline, a phosphodiesterase inhibitor, and L-arginine, a precursor to nitric oxide. This combination may help improve blood flow to the genital tissues. The gel is typically applied to the vulvar or clitoral area before sexual activity to promote arousal, enhance lubrication, and support orgasmic response in women experiencing Female Sexual Arousal Disorder (FSAD) or other sexual dysfunctions.

Product Mechanism of Action

Mechanism of Action^1-5

Aminophylline

A complex of theophylline and ethylenediamine.
Inhibits phosphodiesterase (PDE), leading to increased intracellular cyclic AMP (cAMP) levels.
Elevated cAMP promotes smooth muscle relaxation and vasodilation, improving blood flow to applied areas.
Has mild lipolytic properties, though this effect is more relevant in cosmetic applications.

L-Arginine

A naturally occurring amino acid and precursor to nitric oxide (NO).
Nitric oxide may act as a vasodilator, increasing blood flow by relaxing vascular smooth muscle.
May enhance blood flow, which can increase clitoral and vulvar engorgement, contributing to improved sensitivity and sexual pleasure.

Combined Effect

The combination of aminophylline and L-arginine may synergistically enhance genital blood flow, improving sexual responsiveness and local tissue sensitivity in women.

Product Adverse Reactions

Common (local)^1-5

Skin irritation (redness, itching, tingling)
Burning sensation at the application site
Allergic contact dermatitis (rare)

Systemic (uncommon but possible)^1-5

Nervousness or jitteriness (from aminophylline)
Headache
Nausea
Hypotension

Product Contraindications & Precautions

Contraindications^1-5

Known allergy or hypersensitivity to aminophylline, theophylline, or L-arginine
Active genital infections (e.g., herpes, yeast infections)
Broken or inflamed skin at the application site

Precautions^1-5

Use with caution in individuals with:
Cardiovascular disease (due to potential vasodilation)
Hypotension
Asthma or COPD (aminophylline may interact with systemic medications)
Pregnancy or breastfeeding (safety not established)
Not for use with barrier methods like latex condoms without compatibility testing, as some gels may degrade latex.

Product Storage

Store at 20–25°C (68–77°F) in a dry place, away from direct sunlight and heat. Do not refrigerate or freeze. Keep container tightly closed. Keep out of reach of children.

Product References

Clinical Pharmacology (Elsevier) – aminophylline 100mg tablet Monograph; accessed August 2025 through https://www.clinicalkey.com/pharmacology/monograph/599?aprid=7845
L-Arginine – Patient Handout; NatMed Pro; 2025; https://naturalmedicines-therapeuticresearch-com.lp.hscl.ufl.edu/databases/food,-herbs-supplements/patienthandout.aspx?productid=875&lang=en
Leiblum SR, Wiegel M. Psychotherapeutic interventions for treating female sexual dysfunction. World J Urol. 2002 Jun;20(2):127-36. doi: 10.1007/s00345-002-0266-3. Epub 2002 May 15. PMID: 12107544.
Basson R. Women’s sexual dysfunction: revised and expanded definitions. CMAJ. 2005 May 10;172(10):1327-33. doi: 10.1503/cmaj.1020174. PMID: 15883409; PMCID: PMC557105.
Meston CM, Frohlich PF. The neurobiology of sexual function. Arch Gen Psychiatry. 2000 Nov;57(11):1012-30. doi: 10.1001/archpsyc.57.11.1012. PMID: 11074867.

Product Disclaimer

WPPL operates as a 503A compounding pharmacy and prepares individualized prescription medications pursuant to provider direction. Compounded preparations are not reviewed, tested, or approved by the FDA.

This listing also includes commercially manufactured products for convenience; these items are not compounded by our pharmacy and are sold as provided by their manufacturers. Actual products in stock at time of dispensing may vary due to supply chain variability. Any statements regarding non-compounded products are manufacturer-supplied, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. WPPL does not verify or endorse any therapeutic claims made by manufacturers. Please refer to original labeling for complete product information.

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