Ondansetron

(Commercial Product) Tablets

4 mg  |  8 mg

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Disclaimer: Images are for reference only; actual products may vary.

Product Overview

Ondansetron Description1,2

Ondansetron is a 5-HT₃ receptor antagonist that is used clinically as an antiemetic. It is utilized to prevent and manage nausea and vomiting, particularly in patients undergoing chemotherapy, receiving radiation therapy, or following surgery or other medical procedures.

Mechanism of Action1,2

Serotonin (5-HT₃) receptors are found in the gastrointestinal tract and centrally in the chemoreceptor trigger zone (CTZ) in the brain. Ondansetron prevents serotonin from binding to serotonin receptors in the gastrointestinal tract and the chemoreceptor trigger zone. By preventing serotonin from binding to these receptors, it inhibits vomiting reflexes, specifically when chemotherapy, radiation, and anesthesia is administered.

Common1,2

  • Headache
  • Constipation
  • Fatigue
  • Dizziness

Contraindications1,2

  • Known hypersensitivity to ondansetron or other 5-HT₃ antagonists.

Precautions1,2

  • QT interval prolongation: avoid in patients with risk factors for QT prolongation including congenital long QT syndrome or electrolyte imbalances. (hypokalemia, hypomagnesemia)—QT interval prolongation can lead to torsades de pointes.
  • Hepatic impairment: In severe hepatic dysfunction, do not exceed 8 mg total daily dose.
  • Store at controlled room temperature (20°C to 25°C / 68°F to 77°F)
  • Protect from moisture and light
  • Keep in a tightly closed container
  1. FDA Label – Ondansetron HCL. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/020103s035_020605s019_020781s019lbl.pdf Revised October 2016 Accessed May 22, 2025.
  2. Clinical Pharmacology ondansetron clinical monograph 2025 https://www.clinicalkey.com/pharmacology/

WPPL operates as a 503A compounding pharmacy and prepares individualized prescription medications pursuant to provider direction. Compounded preparations are not reviewed, tested, or approved by the FDA.

This listing also includes commercially manufactured products for convenience; these items are not compounded by our pharmacy and are sold as provided by their manufacturers. Actual products in stock at time of dispensing may vary due to supply chain variability. Any statements regarding non-compounded products are manufacturer-supplied, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. WPPL does not verify or endorse any therapeutic claims made by manufacturers. Please refer to original labeling for complete product information.

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