Minoxidil / Latanoprost

Lotion

10% / 0.06%

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Disclaimer: Images are for reference only; actual products may vary.

Product Overview

Product Description

The following drugs have been combined into a topical formulation for the management of hair loss.

Minoxidil^1-3

Topical minoxidil is a vasodilator originally developed as an oral antihypertensive medication. Hair growth stimulation was observed as a side effect (hypertrichosis, or excessive abnormal hair growth) in patients taking oral minoxidil. Following these observations, minoxidil was FDA-approved for the treatment of androgenetic alopecia in both men and women.

Latanoprost Description^4-8

Latanoprost is a prostaglandin F2α (PGF2α) analog primarily used for the treatment of open-angle glaucoma and ocular hypertension. Evidence indicates that latanoprost can promote hair growth, particularly in androgenetic alopecia and in cases of eyelash or eyebrow hypotrichosis. Its potential for hair regrowth was first noted due to the side effect of increased eyelash growth in patients being treated for glaucoma.

Product Mechanism of Action

Minoxidil^1-3

The drug has many mechanisms in supporting hair growth:

Potassium channel opening: Minoxidil is a K⁺-ATP channel opener, resulting in vasodilation and enhanced blood flow to hair follicles.
Prolongation of the hair cycle: It extends the growth phase of the hair cycle, leading to increased follicle size and more robust hair shafts.
Activation of prostaglandins: May indirectly affect prostaglandin-mediated signaling to stimulate hair follicle activity.
Upregulation of vascular endothelial growth factor (VEGF): Promotes angiogenesis in dermal papillae, improving follicular nourishment.

Latanoprost^4-8

Latanoprost binds to the prostaglandin F2α receptor on hair follicle dermal papilla cells, influencing the hair growth cycle as follows:

Prolongation of Anagen Phase (Growth Phase):

Increases the duration of anagen, resulting in longer and thicker hair shafts.

Stimulation of Melanogenesis:

May enhance pigmentation in vellus hairs, making them appear darker and more terminal-like.

Increased Follicular Density:

Some studies suggest latanoprost may increase the number of follicles actively producing hair, particularly in the eyelash and eyebrow regions, and potentially the scalp.

Product Adverse Reactions

Adverse Reactions^1-8

Minoxidil

Common

Topical minoxidil is generally well tolerated but may cause local effects:

Local side effects (most common):

Scalp irritation, dryness, flaking
Erythema or contact dermatitis (more common with propylene glycol-containing formulations)
Pruritus or burning sensation
Unwanted facial hair growth (esp. in women or if solution drips onto other areas)

Latanoprost

Common

Local irritation (itching, burning, erythema)
Hyperpigmentation of skin (especially around eyelids or eyebrows)
Increased pigmentation of treated hair
Eyelid darkening (rare with scalp use)
Unwanted hair growth if medication spreads to unintended areas
Eye irritation (if it migrates to eye area)

Product Contraindications & Precautions

Contraindications & Precautions^1-8

Minoxidil

Contraindications:

Known hypersensitivity to minoxidil or excipients (e.g., propylene glycol, alcohol)
Discontinuation advised if signs of hypersensitivity or severe irritation occur

Precautions:

Avoid use on broken or inflamed skin to minimize systemic absorption
Not for use in individuals under 18 years unless directed by a physician
Caution in patients with cardiovascular disease (though systemic absorption is typically minimal with proper use)
Avoid ocular contact — rinse thoroughly if accidental exposure occurs
Should not be used during pregnancy or lactation unless clinically indicated and under supervision

Latanoprost

Contraindications:

Known hypersensitivity to latanoprost or prostaglandin analogs
Active ocular conditions if near eyes (without ophthalmologic approval)
History of herpetic keratitis (due to prostaglandin-induced reactivation risk)

Precautions:

Avoid application near the eyes unless specifically prescribed
Use gloves or applicator to prevent unintended hair growth on fingers/hands
Avoid contact with mucous membranes
Patients with a history of uveitis, macular edema, or intraocular surgery should be monitored if periorbital application is required

Product Storage

Store in a cool, dry place, away from direct light and heat; Room temperature (20°C–25°C / 68°F–77°F) is ideal.

Product References

Clinical Pharmacology [Internet].: Elsevier; accessed May 2025; Minoxidil topical monograph. Available from: ClinicalKey; https://www.clinicalkey.com/pharmacology/monograph/408?n=Minoxidil
Rogaine® (minoxidil topical solution) package insert. Johnson & Johnson Consumer Inc. https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=12fd18f0-859c-7b9a-e063-6394a90addbf&type=display Revised March 2024. Accessed June 16, 2025
Goren A, Naccarato T. Minoxidil in the treatment of androgenetic alopecia. Dermatol Ther. 2018 Sep;31(5):e12686.
Johnstone, M. A. (1997). Hypertrichosis and increased pigmentation of eyelashes and adjacent hair in latanoprost therapy. American Journal of Ophthalmology, 120(7), 999–1001.
Blume-Peytavi, U., et al. (2012). Latanoprost stimulates human scalp hair growth in vivo. Journal of the American Academy of Dermatology, 66(5), 807–814.
Kwon, O. S., et al. (2007). Prostaglandin analogs as a potential treatment for hair loss: Latanoprost and bimatoprost in the management of alopecia. International Journal of Dermatology, 46(9), 1044–1048.
Clinical Pharmacology. Elsevier. Latanoprost Monograph. Accessed June 2025
FDA Drug Label: Xalatan (latanoprost ophthalmic solution) https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a98595b3-9f47-48e0-b18d-550a2095f264&type=display Revised May 2023. Accessed June 15, 2025

Product Disclaimer

WPPL operates as a 503A compounding pharmacy and prepares individualized prescription medications pursuant to provider direction. Compounded preparations are not reviewed, tested, or approved by the FDA.

This listing also includes commercially manufactured products for convenience; these items are not compounded by our pharmacy and are sold as provided by their manufacturers. Actual products in stock at time of dispensing may vary due to supply chain variability. Any statements regarding non-compounded products are manufacturer-supplied, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. WPPL does not verify or endorse any therapeutic claims made by manufacturers. Please refer to original labeling for complete product information.

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