Testosterone Cypionate / Enanthate

(90% / 10%) Injection

200 mg/mL

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Product Overview

Testosterone Cypionate / Enanthate Description1-7

Cypionate 90% / Enanthate 10% Injection is a compounded injectable testosterone ester blend composed of 90% testosterone cypionate and 10% testosterone enanthate. Both esters are long-acting formulations commonly used in testosterone replacement therapy (TRT) for the treatment of male hypogonadism.

This blended formulation is designed to take advantage of the complementary pharmacokinetic profiles of testosterone cypionate and testosterone enanthate, with the goal of providing a more consistent and sustained release of testosterone. By doing so, it may help reduce injection frequency and minimize fluctuations in serum testosterone levels.

Testosterone enanthate has an approximate half-life of 7 days, which is slightly shorter than that of testosterone cypionate at approximately 8 days. In contrast, non-esterified (free) testosterone has a very short half-life of approximately 10 minutes. Esterification significantly prolongs testosterone’s duration of action, allowing for more stable therapeutic hormone levels.

Mechanism of Action1,2,5-7

Testosterone cypionate and testosterone enanthate are both esterified forms of testosterone. The esterification occurs on the 17b carbon of the testosterone structure. The esters extend the duration of action and are useful for less frequent, intramuscular, or subcutaneous injections.  Once administered, the esters are cleaved, releasing free testosterone into the bloodstream. Testosterone then binds to androgen receptors in various tissues, exerting anabolic and androgenic effects. Testosterone has a role in influencing the development and maintenance of male secondary sexual characteristics, stimulation of muscle and bone growth, and regulation of libido and mood.

Common1

  • Acne
  • Hypertension
  • Injection site pain or inflammation
  • Mood swings or irritability
  • Increased or decreased libido
  • Gynecomastia

Contraindications 1

  • Known hypersensitivity to testosterone or either ester component
  • Known hypersensitivity to grapeseed oil
  • Males with carcinoma of the breast or known or suspected carcinoma of the prostate
  • Pregnant or breastfeeding women
  • Patients with serious cardiac, hepatic, or renal disease

Precautions 1

  • Monitor hematocrit and hemoglobin levels
  • Regularly assess liver function tests
  • Evaluate lipid profiles periodically
  • Monitor for signs of sleep apnea
  • Use cautiously in patients with a history of cardiovascular disease

Store at 20°C to 25°C (68°F to 77°F) in a dry place, away from heat and light. DO NOT REFRIGERATE. Do not freeze. Keep out of reach of children.

  1. Clinical Pharmacology Testosterone clinical monograph accessed May 8 2025 ; https://www.clinicalkey.com/pharmacology/monograph/595?n=Testosterone 
  2. https://go.drugbank.com/drugs/DB13944 
  3. Pubchem testosterone enanthate. https://pubchem.ncbi.nlm.nih.gov/compound/Testosterone-Enanthate#section=Metabolism-Metabolites. Accessed July 6, 2025
  4. Pubchem testosterone cypionate. https://pubchem.ncbi.nlm.nih.gov/compound/Testosterone-Cypionate#section=Metabolism-Metabolites. Accessed July 6, 2025
  5. Mayo Clinic. Testosterone cypionate (intramuscular route). https://www.mayoclinic.org/drugs-supplements/testosterone-cypionate-intramuscular-route/description/drg-20563731 
  6. Testosterone enanthate [package insert] Hikma Pharmaceuticals USA Inc. Berkeley Heights, NJ 07922, revised January 2021, accessed May 2025 through: https://www.accessdata.fda.gov/spl/data/d56a5e5d-c88f-4f0d-84b4-1be06ca6ebba/d56a5e5d-c88f-4f0d-84b4-1be06ca6ebba.xml
  7. Depo Testosterone(Testosterone Cypionate) [package insert] Pfizer Inc NY, NY 10017, revised July 2018, accessed May 2025 through: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/085635s040lbl.pdf

WPPL operates as a 503A compounding pharmacy and prepares individualized prescription medications pursuant to provider direction. Compounded preparations are not reviewed, tested, or approved by the FDA.

This listing also includes commercially manufactured products for convenience; these items are not compounded by our pharmacy and are sold as provided by their manufacturers. Actual products in stock at time of dispensing may vary due to supply chain variability. Any statements regarding non-compounded products are manufacturer-supplied, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. WPPL does not verify or endorse any therapeutic claims made by manufacturers. Please refer to original labeling for complete product information.

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