Cream
0.025% / 1%
Product Overview
Tretinoin1,2
Tretinoin is a naturally derived form of vitamin A, also known as all-trans-retinoic acid. Retinoids may support the regulation of cell reproduction, proliferation, and differentiation. Tretinoin is believed to promote skin cell turnover, which may enhance skin texture and tone. It is used in the management of acne vulgaris as well as photoaging concerns, including facial wrinkles, skin roughness, and hyperpigmentation. In hyperpigmentation disorders, tretinoin may inhibit the transcription of the enzyme tyrosinase, thereby reducing melanogenesis.
Coenzyme Q10 (CoQ10)3-5
Coenzyme Q10 (CoQ10) is a lipophilic compound naturally present in the body and plays a key role in cellular energy metabolism via the mitochondrial electron transport chain. It also acts as an antioxidant that helps neutralize free radicals. This antioxidant activity and involvement in mitochondrial processes may help reduce visible signs of skin aging and support the maintenance of skin elasticity associated with aging. CoQ10 levels decline with age, which may result in decreased protection against reactive oxygen species.
The combination of tretinoin and CoQ10 supports skin cell turnover while enhancing antioxidant activity, contributing to improved skin integrity.
Tretinoin1,2
Tretinoin binds to retinoic acid receptors (RARs) alpha, beta, and gamma along with retinoid X receptors (RXRs) to block inflammatory mediators. In addition, during the binding to the retinoid acid receptor, the production of procollagen increases to augment collagen type I and III formations.
CoQ103-5
CoQ10 has a critical role as a cofactor for mitochondrial enzyme pathways within cells. Impairments in mitochondrial function disrupt cellular adenosine triphosphate (ATP) production and thereby inhibit the fuel for cellular repair mechanisms and function. Reactive oxygen species accumulate, which in turn can damage mitochondria, cellular membranes, and mitochondrial DNA, accelerating skin aging in a negative feedback loop. Coenzyme Q helps to facilitate mitochondrial activity and maintain energy. CoQ10 inhibits the ability of free radicals to activate mitogen activated protein kinase pathway and the ability of collagenases to form minimizing damage to collagen. It also decreases damage caused by lipid peroxidases to li[pids, proteins and DNA.
Tretinoin1,2
Common
CoQ10 3-5
Contraindications1,2
Precautions1,2
Store at controlled room temperature (20–25°C / 68–77°F). Protect from excessive heat and direct sunlight. Keep the container tightly closed. Do not freeze. Keep out of reach of children.
WPPL operates as a 503A compounding pharmacy and prepares individualized prescription medications pursuant to provider direction. Compounded preparations are not reviewed, tested, or approved by the FDA.
This listing also includes commercially manufactured products for convenience; these items are not compounded by our pharmacy and are sold as provided by their manufacturers. Actual products in stock at time of dispensing may vary due to supply chain variability. Any statements regarding non-compounded products are manufacturer-supplied, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. WPPL does not verify or endorse any therapeutic claims made by manufacturers. Please refer to original labeling for complete product information.
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Providers: Let’s Partner for Better Patient Care
If you are a physician, clinic, or practice seeking a dependable Compounding Pharmacy partner, WP Pharma Labs is here to help. With dedicated account setup, streamlined ordering and responsive service, we support your therapeutic goals with specialized compounds designed for your patients.
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