Testosterone Propionate

Injection

100 mg/mL

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Product Overview

Testosterone Propionate Description1-4

Testosterone Propionate Injection is a compounded injectable formulation containing the testosterone ester, testosterone propionate. It is used in testosterone replacement therapy for the treatment of male hypogonadism. Testosterone propionate has an approximate half-life of 4.5 days. In contrast, non-esterified (free) testosterone has a very short half-life of about 10 minutes. Esterification significantly prolongs the duration of action of testosterone, allowing for more sustained therapeutic effects.

Mechanism of Action1-4

The esterification of testosterone propionate occurs on the 17b carbon of the testosterone structure. The testosterone propionate ester extends the duration of action and is useful for less frequent, intramuscular, or subcutaneous injections.  Once administered, the testosterone propionate ester is cleaved, releasing free testosterone into the bloodstream. Testosterone then binds to androgen receptors in various tissues, exerting anabolic and androgenic effects. Testosterone has a role in influencing the development and maintenance of male secondary sexual characteristics, stimulation of muscle and bone growth, and regulation of libido and mood.

Common1

  • Acne
  • Hypertension
  • Injection site pain or inflammation
  • Mood swings or irritability
  • Increased or decreased libido
  • Gynecomastia

Contraindications1   

  • Known hypersensitivity or intolerance to testosterone or either ester component
  • Males with carcinoma of the breast or known or suspected carcinoma of the prostate
  • Pregnant or breastfeeding women
  • Patients with serious cardiac, hepatic, or renal disease

Precautions1   

  • Monitor hematocrit and hemoglobin levels.
  • Regularly assess liver function tests.
  • Evaluate lipid profiles periodically.
  • Monitor for signs of sleep apnea.
  • Use cautiously in patients with a history of cardiovascular disease.

Store at 20°C to 25°C (68°F to 77°F) in a dry place, away from heat and light. DO NOT REFRIGERATE. Do not freeze. Keep out of reach of children.

  1. Clinical Pharmacology Testosterone clinical monograph accessed September 1 2025 ; https://www.clinicalkey.com/pharmacology/monograph/595?n=Testosterone 
  2. Pubchem testosterone propionate. https://pubchem.ncbi.nlm.nih.gov/compound/Testosterone-Propionate Accessed September 1, 2025
  3. Testosterone Propionate – Steroids Profile – Steroidal.com. https://www.steroidal.com/steroid-profiles/testosterone-propionate/ June 5, 2019 Accessed September 1, 2025
  4. Testosterone propionate: Uses, Interactions, Mechanism of Action | DrugBank Online. https://go.drugbank.com/drugs/DB01420. Accessed September 1, 2025.

WPPL operates as a 503A compounding pharmacy and prepares individualized prescription medications pursuant to provider direction. Compounded preparations are not reviewed, tested, or approved by the FDA.

This listing also includes commercially manufactured products for convenience; these items are not compounded by our pharmacy and are sold as provided by their manufacturers. Actual products in stock at time of dispensing may vary due to supply chain variability. Any statements regarding non-compounded products are manufacturer-supplied, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. WPPL does not verify or endorse any therapeutic claims made by manufacturers. Please refer to original labeling for complete product information.

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