Capsule
3 mg / 100 mg | 7 mg / 100 mg | 14 mg / 100 mg
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Product Overview
Semaglutide Description1-6
Semaglutide is a synthetic glucagon-like peptide-1 receptor agonist (GLP-1 RA) that functions as an incretin mimetic. Incretins are hormones released from the gastrointestinal tract into the systemic circulation that support glycemic control and have been utilized in weight management. When administered orally, semaglutide is indicated for the following use:
Treatment of type 2 diabetes mellitus as an adjunct to diet and exercise
Data indicate that oral semaglutide may produce clinically meaningful outcomes for individuals seeking weight reduction. In a 68-week study, oral semaglutide was associated with an average weight decrease of approximately 15%.
Metformin Description7-9
Metformin is an oral biguanide used to improve glycemic control in adult and pediatric patients 10 years and older with type 2 diabetes mellitus (T2DM). The drug is often 1st line for patients with T2DM. The drug is indicated for
There is evidence that metformin facilitates weight loss and decreases the appetite of patients who are administered the drug.
References
Semaglutide1-6
Semaglutide is an incretin mimetic that works on the glucagon-like peptide-1 (GLP-1) receptor by binding and activating the GLP-1 receptor. It has 94% sequence homology to human GLP-1. GLP-1 medications regulate glucose metabolism after oral consumption of carbohydrates and fats. The drug increases insulin secretion by glucose-dependent insulin synthesis and in vivo secretion of insulin from pancreatic beta cells in the presence of elevated glucose levels. It also suppresses glucagon secretion, slows gastric emptying, reduces food intake, and promotes beta-cell proliferation.
Metformin7-9
As an antidiabetic medication, metformin reduces gluconeogenesis production in the liver, decreases absorption of glucose in the gastrointestinal tract, and increases insulin sensitivity and subsequently peripheral glucose uptake and utilization. The drug facilitates glucose utilization in skeletal and adipose tissue. Metformin is believed to facilitate weight loss by decreasing caloric intake by patients through gastrointestinal adverse effects and appetite is decreased by production of glucagon like peptide 1 production.
Common 3,4,7-9
Gastrointestinal: Nausea, vomiting, diarrhea, constipation, dyspepsia, headache, dizziness.
Contraindications & Precautions3,4,7-9
Contraindications:
Precautions:
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