Progesterone

Cream

20 mg/gm | 30 mg/gm | 40 mg/gm
50 mg/gm | 100 mg/gm | 200 mg/gm

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Disclaimer: Images are for reference only; actual products may vary.

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Product Overview

Product Description

Progesterone Description^1-3

Micronized Progesterone is a bioidentical form of the naturally occurring hormone progesterone, formulated into micron-sized particles to improve oral absorption. It is used in various women’s health applications, including hormone replacement therapy (HRT), management of luteal phase defects, menstrual disorders, infertility treatments, and prevention of endometrial hyperplasia in postmenopausal women receiving estrogen therapy. It can also be compounded into a transdermal cream to allow for more gradual dosing adjustments.

References

FDA Label for Prometrium® (micronized progesterone); accessed July 2025 through: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/019781s013lbl.pdf
Cynthia A. Stuenkel, Susan R. Davis, Anne Gompel, Mary Ann Lumsden, M. Hassan Murad, JoAnn V. Pinkerton, Richard J. Santen, Treatment of Symptoms of the Menopause: An Endocrine Society Clinical Practice Guideline, The Journal of Clinical Endocrinology & Metabolism, Volume 100, Issue 11, 1 November 2015, Pages 3975–4011, accessed July 2025 through: https://doi.org/10.1210/jc.2015-2236
Clinical Pharmacology Progesterone clinical monograph accessed July 2025 through: https://www.clinicalkey.com/pharmacology/monograph/515?n=Progesterone

Product Mechanism of Action

Mechanism of Action^1-3

Progesterone is a steroid hormone primarily secreted by the corpus luteum and, during pregnancy, the placenta, it binds PR-A & PR-B receptors and the primary actions in women include:

Endometrial transformation: Converts the endometrium from a proliferative to a secretory state, supporting implantation and pregnancy.
Regulation of gonadotropin secretion: Via negative feedback on the hypothalamic-pituitary axis.
Stabilization of the endometrium: helps to prevent irregular bleeding in women receiving estrogen therapy.
CNS effects: Modulates mood, sleep, and neuroprotective pathways through GABA-A receptor modulation.

Product Adverse Reactions

Common ^1-3

Drowsiness or sedation
Breast tenderness
Headache
Bloating
Mood changes
Irregular bleeding or spotting
Dizziness

Product Contraindications & Precautions

Contraindications and Precautions^1-3

Contraindications

Micronized progesterone should not be used in individuals with:

Known or suspected pregnancy (when used outside pregnancy-supporting protocols)
Undiagnosed abnormal menstrual bleeding
Known, suspected, or history of breast cancer
Active or history of thromboembolic disorders (stroke, DVT, heart attack etc…)
Liver dysfunction or disease
Hypersensitivity to progesterone or any formulation components

Precautions

Use in patients with a history of depression should be monitored closely
Caution in cardiovascular disease, migraine, or seizure disorders
In women with a uterus, progesterone is required alongside estrogen to prevent endometrial hyperplasia

Product Storage

Store at 20°C to 25°C (68°F to 77°F) in a dry place, away from heat and light. Keep out of reach of children.

Product References

FDA Label for Prometrium® (micronized progesterone); accessed July 2025 through: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/019781s013lbl.pdf
Cynthia A. Stuenkel, Susan R. Davis, Anne Gompel, Mary Ann Lumsden, M. Hassan Murad, JoAnn V. Pinkerton, Richard J. Santen, Treatment of Symptoms of the Menopause: An Endocrine Society Clinical Practice Guideline, The Journal of Clinical Endocrinology & Metabolism, Volume 100, Issue 11, 1 November 2015, Pages 3975–4011, accessed July 2025 through: https://doi.org/10.1210/jc.2015-2236
Clinical Pharmacology Progesterone clinical monograph accessed July 2025 through: https://www.clinicalkey.com/pharmacology/monograph/515?n=Progesterone

Product Disclaimer

This information is for educational purposes only.

This compounded product has not been reviewed, approved, or evaluated by the Food and Drug Administration for safety and effectiveness. This product is not intended to diagnose, treat, cure, or prevent any disease. No claims are made regarding treatment, cure, or prevention of any disease or condition.

This information is a summary. It may not cover all possible drug information about this product. For complete product information, refer to the manufacturer’s prescribing information and labeling. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A WP Pharma Labs pharmacist will be happy to answer any questions. For consultation, please call 1-800-441-0048.

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