Bi-Test (Enanthate 75% / Cypionate 25%)

Injection

200 mg/mL

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Product Overview

Bi-Test Description1,2

Bi-Test is a compounded injectable testosterone formulation containing 75% testosterone enanthate and 25% testosterone cypionate. Both components are long-acting testosterone esters that have been used in testosterone replacement therapy (TRT) for the management of male hypogonadism. This blend is designed to utilize the pharmacokinetic characteristics of each ester to support a more consistent and sustained release of testosterone, which may help reduce injection frequency and limit fluctuations in hormone levels.

References

  1. Clinical Pharmacology Testosterone clinical monograph accessed May 8 2025; https://www.clinicalkey.com/pharmacology/monograph/595?n=Testosterone
  2. https://go.drugbank.com/drugs/DB13944

Mechanism of Action1,2,3,4

Testosterone enanthate and testosterone cypionate are both esterified forms of testosterone, designed for intramuscular injection. Once administered, the esters are cleaved, releasing free testosterone into the bloodstream. Testosterone then binds to androgen receptors in various tissues, exerting anabolic and androgenic effects. These effects include the development and maintenance of male secondary sexual characteristics, stimulation of muscle and bone growth, and regulation of libido and mood.

Adverse Reactions1

  • Acne
  • Hypertension
  • Injection site pain or inflammation
  • Mood swings or irritability
  • Increased or decreased libido
  • Gynecomastia

Contraindications1

  • Known hypersensitivity to testosterone or either ester (cypionate or enanthate).
  • Known hypersensitivity to grapeseed oil.
  • Males with carcinoma of the breast or known or suspected carcinoma of the prostate.
  • Pregnant or breastfeeding women.
  • Patients with serious cardiac, hepatic, or renal disease.

Precautions1

  • Monitor hematocrit and hemoglobin levels.
  • Regularly assess liver function tests.
  • Evaluate lipid profiles periodically.
  • Monitor for signs of sleep apnea.
  • Use cautiously in patients with a history of cardiovascular disease.

Store Bi-Test at 20°C to 25°C (68°F to 77°F) in a dry place, away from heat and light. Do not freeze. Keep out of reach of children.

  1. Clinical Pharmacology Testosterone clinical monograph accessed May 8 2025; https://www.clinicalkey.com/pharmacology/monograph/595?n=Testosterone
  2. https://go.drugbank.com/drugs/DB13944
  3. Mayo Clinic. Testosterone cypionate (intramuscular route). https://www.mayoclinic.org/drugs-supplements/testosterone-cypionate-intramuscular-route/description/drg-20563731
  4. Testosterone enanthate [package insert] Hikma Pharmaceuticals USA Inc. Berkeley Heights, NJ 07922, revised January 2021, accessed May 08 2025 through: https://www.accessdata.fda.gov/spl/data/d56a5e5d-c88f-4f0d-84b4-1be06ca6ebba/d56a5e5d-c88f-4f0d-84b4-1be06ca6ebba.xml
  5. Depo Testosterone(Testosterone Cypionate) [package insert] Pfizer Inc NY, NY 10017, revised July 2018, accessed May 08 2025 through: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/085635s040lbl.pdf
This information is for educational purposes only.
This compounded product has not been reviewed, approved, or evaluated by the Food and Drug Administration for safety and effectiveness. This product is not intended to diagnose, treat, cure, or prevent any disease. No claims are made regarding treatment, cure, or prevention of any disease or condition.
This information is a summary. It may not cover all possible drug information about this product. For complete product information, refer to the manufacturer’s prescribing information and labeling. Call your doctor for medical advice and/or about side effects. You may report side effects to the FDA at 1-800-FDA-1088. A WP Pharma Labs pharmacist will be happy to answer any questions. For consultation, please call 1-800-441-0048.

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