(Navalene-Gel) Facial Gel
5% / 0.1%
Product Overview
This compounded skincare formulation contains niacinamide and tretinoin and is intended to support healthy-looking skin. These ingredients are commonly chosen for appearance-related skin concerns, including those affecting skin tone and texture.
Niacinamide1-3
Niacinamide is a water-soluble form of vitamin B3 that plays an essential role in cellular metabolism. Niacin and niacinamide are both forms of vitamin B3, differing slightly in chemical structure. Niacinamide has been shown to support the skin barrier and to exhibit anti-inflammatory, antioxidant, and skin-brightening properties. When applied topically, niacinamide has been shown to be helpful for acne vulgaris, melasma, psoriasis, and aging skin.
Adapalene4-6
Adapalene is a third-generation retinoid that has been used for a variety of skin conditions, including acne vulgaris, photoaging, melasma, and hyperpigmentation disorders. It demonstrates anti-inflammatory and comedolytic activity.
Niacinamide1-3
Niacinamide has various mechanisms of activity to support skin health. Niacinamide is a precursor to the NAD(P) family of coenzymes. These coenzymes are important for metabolic activity in the skin. The reduced form, NAD(P)H, has antioxidant activity and works to neutralize free radicals. Niacinamide provides anti-inflammatory activity and decreases sebum excretion. It has been shown to improve acne vulgaris by affecting neutrophil chemotaxis and suppresses cytokine-mediated induction of nitric oxide synthase. In addition, niacinamide may prevent photoimmunosuppression and photocarcinogenesis, prevent loss of collagen in the dermal layer of skin, and improve the barrier function of the skin. Niacinamide may help with skin lines and wrinkles 1) by increasing collagen production or 2) by reducing the amount of dermal glycosaminoglycans that are seen with photodamaged or wrinkled skin. Niacinamide supports the barrier function of the skin by increasing the lipid and protein stratum corneum. This increase in lipid and protein decreases the trans-epidermal water loss and provides resistance to skin damage from damaging agents. Niacinamide also is thought to inhibit the transfer of melanin from the melanocytes to keratinocytes to decrease hyperpigmentation of skin.
Adapalene4-6
Adapalene binds to retinoic acid receptors and inhibits cell proliferation. It targets keratinization, inflammation, and the differentiation of follicular epithelial cells. It also accelerates the turnover of dead skin cells.
Niacinamide1-3,7
Common
Tretinoin4-6
Common
Contraindications1-7
Precautions1-7
Store at 20–25°C (68–77°F), in a cool, dry place, away from heat and direct sunlight. Do not freeze. Keep container tightly closed and out of reach of children .
WPPL operates as a 503A compounding pharmacy and prepares individualized prescription medications pursuant to provider direction. Compounded preparations are not reviewed, tested, or approved by the FDA.
This listing also includes commercially manufactured products for convenience; these items are not compounded by our pharmacy and are sold as provided by their manufacturers. Any statements regarding non-compounded products are manufacturer-supplied, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. WPPL does not verify or endorse any therapeutic claims made by manufacturers. Please refer to original labeling for complete product information.
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Providers: Let’s Partner for Better Patient Care
If you are a physician, clinic, or practice seeking a dependable Compounding Pharmacy partner, WP Pharma Labs is here to help. With dedicated account setup, streamlined ordering and responsive service, we support your therapeutic goals with specialized compounds designed for your patients.
To check product availability, check on the status of an existing order, request refills:
orders@wppharmalabs.com
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