(DHLMT for Men) Solution
0.3% / 1% / 0.05% / 6.5% / 0.01%
Product Overview
This topical formulation for men combines dutasteride, hydrocortisone, latanoprost, minoxidil, and tretinoin in a preparation intended to address hair thinning associated with androgenetic alopecia. Each component has a distinct mechanism of action related to dihydrotestosterone activity, follicular processes, inflammatory response, and penetration of active ingredients. The formulation is designed to support hair follicle function and overall scalp condition.
Dutasteride Description1-3
Dutasteride is a 5-alpha reductase inhibitor and a 4-aza analog of testosterone. It has been studied in relation to androgenetic alopecia, commonly referred to as male pattern hair loss.
Hydrocortisone4,5
Hydrocortisone is the synthetic form of cortisol, a hormone naturally produced by the adrenal glands, and exhibits both glucocorticoid and mineralocorticoid activity. When applied topically, hydrocortisone demonstrates anti-inflammatory, antipruritic, anti-mitotic, and immunosuppressive effects. Among topical corticosteroids, hydrocortisone is considered a low-potency option.
Latanoprost6-10
Latanoprost works by mimicking prostaglandin F2α (PGF2α) to minimize glaucoma and to stimulate hair growth. There is evidence that the drug promotes hair growth, particularly in androgenetic alopecia (AGA) and eyelash/eyebrow hypotrichosis.6-8 Its role in hair regrowth was first noted due to its adverse effect of increased eyelash growth in glaucoma patients.
Minoxidil11-13
Topical minoxidil is a vasodilator that was originally developed as an oral antihypertensive medication. Its association with hair growth was identified following reports of hypertrichosis in patients receiving oral minoxidil. Subsequently, topical minoxidil received FDA approval for the treatment of androgenetic alopecia in both men and women.
Tretinoin14-18
Tretinoin is a naturally occurring derivative of vitamin A, also known as all-trans-retinoic acid. Retinoids may participate in the regulation of cell reproduction, proliferation, and differentiation. When used in combination with minoxidil, tretinoin has been associated with increased expression of certain markers related to hair growth, including Erk, Akt, Bcl-2, and Bax.
Dutasteride1-3
Dutasteride is a 4-azo analog of testosterone. It competitively and selectively inhibits both reproductive tissues (type 2) and skin and hepatic (type 1) 5α-reductase. This activity of dutasteride prevents the conversion of testosterone to dihydrotestosterone and significantly suppresses serum dihydrotestosterone levels. The type II 5-alpha-reductase isozyme is primarily found in prostate, seminal vesicles, epididymides, and hair follicles, as well as liver. Dihydrotestosterone has been shown to increase prostate growth and can lead to hair thinning.
Hydrocortisone4,5
The anti-inflammatory effects of topical hydrocortisone may occur through vasoconstriction. The vasoconstriction minimizes inflammatory mediators delivered to the inflamed area. Topical hydrocortisone may also inhibit the release of phospholipase A2, which reduces prostaglandins and leukotriene. Lastly, topical hydrocortisone inhibits DNA and transcription factors related to inflammation. It does this by increasing the expression of anti-inflammatory genes and indirectly inhibit inflammatory transcription factors, such as NF-kB, to decrease the expression of pro-inflammatory genes.
Topical hydrocortisone also has an anti-mitotic effect by decreasing epidermal mitosis mediated through an increase in lipocortin, an endogenous glucocorticoid-regulated protein.
Topical hydrocortisone also inhibits humoral factors in the inflammatory response by suppressing immune cells from maturing, differentiating and proliferating.
Latanoprost6-10
Latanoprost binds to the prostaglandin F2α receptor on hair follicle dermal papilla cells, influencing the hair growth cycle as follows:
Increases the duration of anagen, which may result in longer and thicker hair shafts.
May enhance pigmentation in vellus hairs, which may make them appear darker and more terminal-like.
Some studies suggest latanoprost may increase the number of follicles actively producing hair, particularly in the eyelash and eyebrow regions, and potentially the scalp.
Minoxidil11-13
The drug has many mechanisms in supporting hair growth:
Tretinoin14-17
Tretinoin may have several mechanisms to facilitate hair growth including the following:
Dutasteride1-3
Common
With systematic absorption (rare)
Hydrocortisone4
Common
Latanoprost9,10
Common
Minoxidil11-13
Common
Topical minoxidil is generally well tolerated but may cause local effects:
Tretinoin14
Common
Contraindications 1-4,9,10-14
Precautions 1-4,9,10-14
Store at room temperatures between (59-86°F). Protect from light and keep the container tightly closed. Women should not handle crushed or broken finasteride tablets when they are pregnant or may potentially be pregnant because of the possibility of absorption of finasteride and the subsequent potential risk to a male fetus. Keep out of reach of children and pets.
WPPL operates as a 503A compounding pharmacy and prepares individualized prescription medications pursuant to provider direction. Compounded preparations are not reviewed, tested, or approved by the FDA.
This listing also includes commercially manufactured products for convenience; these items are not compounded by our pharmacy and are sold as provided by their manufacturers. Any statements regarding non-compounded products are manufacturer-supplied, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. WPPL does not verify or endorse any therapeutic claims made by manufacturers. Please refer to original labeling for complete product information.
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