Facial Cream
15% / 0.3%
Product Overview
Ascorbic Acid / Estriol Cream is a compounded topical formulation used to address signs of skin aging, including fine lines, dullness, dryness, and reduced elasticity. Ascorbic acid functions as an antioxidant and may offer collagen-supporting properties, while estriol may contribute to skin hydration and structural support.
Ascorbic Acid1-5
Ascorbic acid, also known as vitamin C, is a water-soluble vitamin with antioxidant properties and serves as a key cofactor in collagen synthesis, carnitine and catecholamine metabolism, and dietary iron absorption. It plays an important role in maintaining skin integrity. In addition to its antioxidant effects on the skin, ascorbic acid exhibits anti-inflammatory activity, acts as a depigmenting agent, and supports collagen formation. Deficiency of ascorbic acid is associated with skin aging, making topical supplementation an approach used in skin anti-aging strategies.
Ascorbic acid is not synthesized by the body and must be obtained through dietary intake or supplementation. Common dietary sources include citrus fruits, berries, tomatoes, potatoes, and green leafy vegetables.
Estriol6-10
Micronized estriol is a bioidentical form of estriol (E3), one of the three naturally occurring estrogens in women, along with estradiol and estrone. Estriol is considered the weakest estrogen, with lower receptor binding affinity and a shorter duration of action compared to estradiol (E2). Despite its lower potency, estriol has demonstrated potential skin-related properties, including support for dermal thickness and elasticity. It is most commonly used in combination with estradiol in postmenopausal women with estrogen deficiency. Estriol is frequently compounded in a transdermal cream, allowing for gradual and adjustable dosing.
Ascorbic Acid1-5
Ascorbic acid functions in the aqueous compartments of the cell. As an antioxidant, ascorbic acid neutralizes free radicals by donating electrons to prevent oxidative stress. Reactive oxygen species are formed when skin is exposed to ultraviolet light forming superoxide ions, peroxide and singlet oxygen species. Ascorbic acid facilitates collagen development. It plays an important role in the maturation of collagen. It is a critical co-factor for prolyl hydroxylase and lysl hydroxylase. The level of ascorbic acid in the skin is directly tied to the structural integrity of dermal collagen. As a depigmenting agent, ascorbic acid interacts with copper ions at the tyrosinase‑active site and inhibits action of the enzyme tyrosinase, thereby minimizing the melanin formation. Ascorbic acid interferes with NFkB activity and thus decreases the activity of a number of pro‑inflammatory cytokines such as TNF‑alfa, IL1, IL6 and IL8.
Estriol6-10
Estriol acts by binding to estrogen receptors alpha (ERα) and beta (ERβ) in estrogen-responsive tissues, particularly the vaginal epithelium, bladder, urethra, and pelvic floor musculature.
Mechanisms and Effects:
Common6-10
Systemic (rare at low doses)6-10
Contraindications6-10
Precautions6-10
Use caution in:
Store at 20°C to 25°C (68°F to 77°F) in a dry place, away from heat and light. Keep out of reach of children.
WPPL operates as a 503A compounding pharmacy and prepares individualized prescription medications pursuant to provider direction. Compounded preparations are not reviewed, tested, or approved by the FDA.
This listing also includes commercially manufactured products for convenience; these items are not compounded by our pharmacy and are sold as provided by their manufacturers. Actual products in stock at time of dispensing may vary due to supply chain variability. Any statements regarding non-compounded products are manufacturer-supplied, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. WPPL does not verify or endorse any therapeutic claims made by manufacturers. Please refer to original labeling for complete product information.
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