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depo estradiol

Depo® Estradiol Cypionate

(Commercial Product) Injection, USP

5 mg/mL

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Disclaimer: Images are for reference only; actual products may vary.

Product Overview

Estradiol Cypionate Description1,2,3

Estradiol Cypionate is a long-acting injectable ester of 17β-estradiol, the primary estrogen produced by the ovaries in premenopausal women. It is formulated for intramuscular (IM) administration, usually in oil-based solutions that provide slow release and extended systemic activity.

Mechanism of Action1,2,3

Estradiol binds to estrogen receptors, which are widely distributed in reproductive tissues, the brain, bone, liver, and vasculature. Upon receptor binding, estradiol influences gene transcription, which may lead to a broad range of systemic and local effects:

  • Endometrial proliferation in the absence of a progesterone or progestogen.
  • Negative feedback on the hypothalamic-pituitary axis (reduces FSH and LH)
  • Maintenance of bone density via inhibition of bone resorption
  • Thermoregulatory stabilization, reducing hot flashes and night sweats
  • Cardiovascular and lipid effects (e.g., improves HDL/LDL ratio)
  • Neurotransmitter modulation affecting mood and cognition

Common1,2,3

  • Breast tenderness
  • Nausea
  • Headache
  • Fluid retention
  • Bloating
  • Mood changes
  • Breakthrough vaginal bleeding or spotting
  • Injection site discomfort

Absolute Contraindications1,2,3

  • Known or suspected breast cancer or estrogen-dependent neoplasia
  • Undiagnosed abnormal genital bleeding
  • Active or history of thromboembolic disorders (e.g., DVT, PE, stroke)
  • Active liver dysfunction or disease
  • Known hypersensitivity to estradiol cypionate or its formulation components (e.g., sesame oil)

Precautions1,2,3

  • Women with a history of hormone-sensitive cancers
  • Hypertension or cardiovascular disease
  • Migraine with aura
  • Diabetes mellitus
  • Hypertriglyceridemia
  • In women with an intact uterus, a progestogen must be co-administered to reduce the risk of endometrial hyperplasia and cancer.
  • Routine monitoring of breast, pelvic, and cardiovascular health is advised during therapy.
  • Store at controlled room temperature (20°C to 25°C / 68°F to 77°F)
  • Protect from moisture and light
  • Keep in a tightly closed container
  1. Clinical Pharmacology (Elsevier) – Estradiol Cypionate Monograph; accessed August 2025 through: https://www.clinicalkey.com/pharmacology/monograph/1330?n=Estradiol
  2. FDA Label – Depo-Estradiol (estradiol cypionate injection); accessed August 2025 through: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/009747s037lbl.pdf
  3. MedlinePlus – Estradiol Injection (systemic) accessed August 2025 through: https://medlineplus.gov/druginfo/meds/a682750.html

WPPL operates as a 503A compounding pharmacy and prepares individualized prescription medications pursuant to provider direction. Compounded preparations are not reviewed, tested, or approved by the FDA.

This listing also includes commercially manufactured products for convenience; these items are not compounded by our pharmacy and are sold as provided by their manufacturers. Actual products in stock at time of dispensing may vary due to supply chain variability. Any statements regarding non-compounded products are manufacturer-supplied, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. WPPL does not verify or endorse any therapeutic claims made by manufacturers. Please refer to original labeling for complete product information.

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