Tadalafil / Testosterone

Daily Use (Ship Cold) Mini-Troche

2.5 mg / 1 mg  |  5 mg / 2 mg

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Product Overview

Tadalafil1,2

Tadalafil is a phosphodiesterase type 5 (PDE5) inhibitor with an average terminal half-life exceeding 17 hours. This duration is significantly longer than that of other PDE5 inhibitors, such as sildenafil and vardenafil. The extended half-life supports both once-daily and on-demand dosing options. Tadalafil is indicated for the treatment of pulmonary arterial hypertension (PAH), erectile dysfunction (ED), benign prostatic hypertrophy (BPH), or the combined management of ED and BPH.

Testosterone3-6

Micronized testosterone (natural) is plant-derived, most commonly sourced from yams, and is chemically processed to produce bioidentical testosterone. In contrast to injectable testosterone formulations, free testosterone is rapidly metabolized following absorption, which necessitates more frequent administration compared to weekly or monthly injectable forms such as cypionate or enanthate. It is commonly used to treat male

Tadalafil1-2,7

Phosphodiesterase (PDE) has many isoforms and is an enzyme that has many functions in the body including degrading the effect of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). PDE5 is an enzyme that is found in many parts of the body including in the smooth muscle of the corpus cavernosum, prostate, bladder, the vascular and visceral smooth muscle, skeletal muscle, urethra, platelets, kidney, lung, cerebellum, heart, liver, testis, seminal vesicle, and pancreas. Tadalafil is a selective inhibitor of PDE5, the enzyme responsible for the degradation of cGMP. The drug has selective activity on PDE5 than other phosphodiesterase isoforms. Tadalafil activity on PDE5 is more than 10,000-fold more than for PDE1, PDE2, PDE4, and PDE7 enzymes. Increased cGMP leads to smooth muscle relaxation in the corpus cavernosum which can help in maintaining an erection.

Testosterone3-6

Testosterone binds to androgen receptors in various tissues, exerting anabolic and androgenic effects. These effects include the development and maintenance of male secondary sexual characteristics, stimulation of muscle and bone growth, and regulation of libido and mood in both men and women.

Common 

Tadalafil1,2

  • Headache
  • Dyspepsia
  • Flushing
  • Back pain and myalgia (typically delayed onset, resolving within 48 hours)
  • Nasal congestion
  • Pain in limbs

Testosterone3

  • Acne
  • Hypertension
  • Mood swings or irritability
  • Increased or decreased libido
  • Gynecomastia

Contraindications1,2,4,5

  • Known hypersensitivity to tadalafil or testosterone or excipients used
  • Use of nitrates and guanylate cyclase (GC) stimulators therapy, such as riociguat due to risk of life-threatening hypotension
  • Males with carcinoma of the breast or known or suspected carcinoma of the prostate
  • Pregnant or breastfeeding women
  • Patients with serious cardiac, hepatic, or renal disease

Precautions1,2,4,5

  • Use with caution in patients with:
  • Severe hepatic impairment (Child-Pugh Class C)
  • Severe renal impairment (creatinine clearance <30 mL/min)
  • Retinitis pigmentosa (rare inherited retinal disorder)
  • History of NAION (non-arteritic anterior ischemic optic neuropathy)
  • Recent history of myocardial infarction, stroke, or unstable angina
  • Monitor hematocrit and hemoglobin levels
  • Regularly assess liver function tests
  • Evaluate lipid profiles periodically

Store at controlled room temperature 20–25°C (68–77°F) or may be stored in the refrigerator. Keep in a dry place. Protect from light, heat, and moisture. Keep out of reach of children and pets.

  1. Tadalafil Prescribing Information – Eli Lilly. www.accessdata.fda.gov/drugsatfda_docs/label/2011/021368s20s21lbl.pdf Revised October 2011. Accessed May 31, 2025
  2. Clinical Pharmacology Tadalafil clinical monograph 2025 https://www.clinicalkey.com/pharmacology/ 
  3. Clinical Pharmacology Testosterone clinical monograph accessed June 17 2025 ; https://www.clinicalkey.com/pharmacology/monograph/595?n=Testosterone
  4. Tauchen J, Jurášek M, Huml L, Rimpelová S. Medicinal Use of Testosterone and Related Steroids Revisited. Molecules. 2021 Feb 15;26(4):1032. doi: 10.3390/molecules26041032. PMID: 33672087; PMCID: PMC7919692.
  5. AndroGel (testosterone gel 1.62% for topical use) [package insert] AbbVie US LLC , revised May 2013, accessed June 2025 through: https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021015s036lbl.pdf https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/085635s040lbl.pdf
  6. Clayton AH, Goldstein I, Kim NN, Althof SE, Faubion SS, Faught BM, Parish SJ, Simon JA, Vignozzi L, Christiansen K, Davis SR, Freedman MA, Kingsberg SA, Kirana PS, Larkin L, McCabe M, Sadovsky R. The International Society for the Study of Women’s Sexual Health Process of Care for Management of Hypoactive Sexual Desire Disorder in Women. Mayo Clin Proc. 2018 Apr;93(4):467-487. doi: 10.1016/j.mayocp.2017.11.002. Epub 2018 Mar 12. PMID: 29545008.
  7. Padda IS, Tripp J. Phosphodiesterase Inhibitors. [Updated 2023 Jun 26]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025

WPPL operates as a 503A compounding pharmacy and prepares individualized prescription medications pursuant to provider direction. Compounded preparations are not reviewed, tested, or approved by the FDA.

This listing also includes commercially manufactured products for convenience; these items are not compounded by our pharmacy and are sold as provided by their manufacturers. Actual products in stock at time of dispensing may vary due to supply chain variability. Any statements regarding non-compounded products are manufacturer-supplied, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. WPPL does not verify or endorse any therapeutic claims made by manufacturers. Please refer to original labeling for complete product information.

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